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3im5

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{{Seed}}
 
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[[Image:3im5.png|left|200px]]
 
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==Crystal structure of mouse Ryanodine Receptor 2 (residues 1-217)==
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The line below this paragraph, containing "STRUCTURE_3im5", creates the "Structure Box" on the page.
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<StructureSection load='3im5' size='340' side='right'caption='[[3im5]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3im5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IM5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3im5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3im5 OCA], [https://pdbe.org/3im5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3im5 RCSB], [https://www.ebi.ac.uk/pdbsum/3im5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3im5 ProSAT]</span></td></tr>
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{{STRUCTURE_3im5| PDB=3im5 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RYR2_MOUSE RYR2_MOUSE] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10473538</ref> <ref>PMID:9628868</ref> <ref>PMID:21098440</ref> <ref>PMID:20431056</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/3im5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3im5 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of mouse Ryanodine Receptor 2 (residues 1-217)===
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==See Also==
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*[[Ryanodine receptor 3D structures|Ryanodine receptor 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19913485}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19913485 is the PubMed ID number.
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</StructureSection>
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-->
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_19913485}}
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==About this Structure==
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3IM5 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IM5 OCA].
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==Reference==
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<ref group="xtra">PMID:19913485</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Lobo, P A.]]
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[[Category: Lobo PA]]
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[[Category: Petegem, F Van.]]
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[[Category: Van Petegem F]]
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[[Category: Arvc2]]
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[[Category: Arvd2]]
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[[Category: Calcium release channel]]
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[[Category: Cardiac arrhythmia]]
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[[Category: Cardiac channel]]
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[[Category: Cpvt]]
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[[Category: Ion channel]]
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[[Category: Ion transport]]
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[[Category: Ionic channel]]
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[[Category: Ryanodine receptor 2]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 2 09:08:53 2009''
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Current revision

Crystal structure of mouse Ryanodine Receptor 2 (residues 1-217)

PDB ID 3im5

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