3gib

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{{Seed}}
 
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[[Image:3gib.png|left|200px]]
 
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==Crystal Structure of the Complex of the E. coli Hfq with Poly(A)==
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The line below this paragraph, containing "STRUCTURE_3gib", creates the "Structure Box" on the page.
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<StructureSection load='3gib' size='340' side='right'caption='[[3gib]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gib]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GIB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
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{{STRUCTURE_3gib| PDB=3gib | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gib OCA], [https://pdbe.org/3gib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gib RCSB], [https://www.ebi.ac.uk/pdbsum/3gib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gib ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HFQ_ECOLI HFQ_ECOLI] RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32. Binds with high specificity to tRNAs. In vitro, stimulates synthesis of long tails by poly(A) polymerase I. Required for RNA phage Qbeta replication.<ref>PMID:805130</ref> <ref>PMID:10677490</ref> <ref>PMID:11222598</ref> <ref>PMID:17158661</ref> <ref>PMID:19909729</ref> Seems to play a role in persister cell formation; upon overexpression decreases persister cell formation while deletion increases persister formation.<ref>PMID:805130</ref> <ref>PMID:10677490</ref> <ref>PMID:11222598</ref> <ref>PMID:17158661</ref> <ref>PMID:19909729</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gi/3gib_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gib ConSurf].
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<div style="clear:both"></div>
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===Crystal Stucture of the Complex of the E. coli Hfq with Poly(A)===
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==See Also==
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*[[Protein Hfq 3D structures|Protein Hfq 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19889981 is the PubMed ID number.
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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{{ABSTRACT_PUBMED_19889981}}
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[[Category: Large Structures]]
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[[Category: Brennan RG]]
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==About this Structure==
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[[Category: Link TM]]
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3GIB is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GIB OCA].
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[[Category: Valentin-Hansen P]]
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==Reference==
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<ref group="xtra">PMID:19889981</ref><references group="xtra"/>
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[[Category: Escherichia coli k-12]]
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[[Category: Brennan, R G.]]
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[[Category: Link, T M.]]
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[[Category: Valentin-Hansen, P.]]
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[[Category: Degradosome component]]
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[[Category: Dna-binding]]
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[[Category: Hfq-rna complex]]
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[[Category: Rna binding protein]]
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[[Category: Rna binding protein/rna complex]]
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[[Category: Rna-binding]]
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[[Category: Stress response]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 2 09:17:48 2009''
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Current revision

Crystal Structure of the Complex of the E. coli Hfq with Poly(A)

PDB ID 3gib

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