3glw

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{{Seed}}
 
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[[Image:3glw.png|left|200px]]
 
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==Quaternary Structure of Drosophila melanogaster IC/Tctex-1/LC8; Allosteric Interactions of Dynein Light Chains with Dynein Intermediate Chain==
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The line below this paragraph, containing "STRUCTURE_3glw", creates the "Structure Box" on the page.
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<StructureSection load='3glw' size='340' side='right'caption='[[3glw]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3glw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GLW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3glw OCA], [https://pdbe.org/3glw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3glw RCSB], [https://www.ebi.ac.uk/pdbsum/3glw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3glw ProSAT]</span></td></tr>
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{{STRUCTURE_3glw| PDB=3glw | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYL1_DROME DYL1_DROME] Acts as a non-catalytic accessory component of a dynein complex (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/3glw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3glw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dynein light chains are thought to increase binding efficiency of dynein intermediate chain to both dynein heavy chain and dynactin, but their exact role is not clear. Isothermal titration calorimetry and x-ray crystallography reported herein indicate that multivalency effects underlie efficient dynein assembly and regulation. For a ternary complex of a 60-amino acid segment of dynein intermediate chain (IC) bound to two homodimeric dynein light chains Tctex1 and LC8, there is a 50-fold affinity enhancement for the second light chain binding. For a designed IC construct containing two LC8 sites, observed the 1000-fold enhancement reflects a remarkably pure entropic chelate effect of a magnitude commensurate with theoretical predictions. The lower enhancement in wild-type IC is attributed to unfavorable free energy changes associated with incremental interactions of IC with Tctex1. Our results show assembled dynein IC as an elongated, flexible polybivalent duplex, and suggest that polybivalency is an important general mechanism for constructing stable yet reversible and functionally versatile complexes.
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===Quaternary Structure of Drosophila melanogaster IC/Tctex-1/LC8; Allosteric Interactions of Dynein Light Chains with Dynein Intermediate Chain===
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Multivalency in the assembly of intrinsically disordered Dynein intermediate chain.,Hall J, Karplus PA, Barbar E J Biol Chem. 2009 Nov 27;284(48):33115-21. Epub 2009 Sep 16. PMID:19759397<ref>PMID:19759397</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3glw" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19759397}}, adds the Publication Abstract to the page
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*[[Dynein 3D structures|Dynein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19759397 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19759397}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3GLW is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GLW OCA].
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==Reference==
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<ref group="xtra">PMID:19759397</ref><references group="xtra"/>
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Barbar, E J.]]
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[[Category: Large Structures]]
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[[Category: Hall, J D.]]
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[[Category: Barbar EJ]]
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[[Category: Karplus, P A.]]
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[[Category: Hall JD]]
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[[Category: Allostery]]
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[[Category: Karplus PA]]
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[[Category: Chelate effect]]
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[[Category: Contractile protein]]
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[[Category: Cytoplasm]]
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[[Category: Dynein]]
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[[Category: Dynein light chain]]
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[[Category: Entropy]]
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[[Category: Ic]]
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[[Category: Intermediate chain]]
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[[Category: Lc8]]
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[[Category: Microtubule]]
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[[Category: Motor protein]]
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[[Category: Multivalent.]]
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[[Category: Tctex]]
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[[Category: Tctex-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 9 14:07:53 2009''
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Current revision

Quaternary Structure of Drosophila melanogaster IC/Tctex-1/LC8; Allosteric Interactions of Dynein Light Chains with Dynein Intermediate Chain

PDB ID 3glw

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