3jqh

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{{Seed}}
 
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[[Image:3jqh.png|left|200px]]
 
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==Structure of the neck region of the glycan-binding receptor DC-SIGNR==
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The line below this paragraph, containing "STRUCTURE_3jqh", creates the "Structure Box" on the page.
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<StructureSection load='3jqh' size='340' side='right'caption='[[3jqh]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3jqh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JQH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.201&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jqh OCA], [https://pdbe.org/3jqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jqh RCSB], [https://www.ebi.ac.uk/pdbsum/3jqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jqh ProSAT]</span></td></tr>
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{{STRUCTURE_3jqh| PDB=3jqh | SCENE= }}
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</table>
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== Function ==
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===Structure of the neck region of the glycan-binding receptor DC-SIGNR===
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[https://www.uniprot.org/uniprot/CLC4M_HUMAN CLC4M_HUMAN] Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus.<ref>PMID:11257134</ref> <ref>PMID:11226297</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 19835887 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/3jqh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_19835887}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jqh ConSurf].
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3JQH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQH OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:19835887</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Drickamer, K.]]
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[[Category: Large Structures]]
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[[Category: Feinberg, H.]]
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[[Category: Drickamer K]]
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[[Category: Taylor, M E.]]
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[[Category: Feinberg H]]
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[[Category: Tso, C K.W.]]
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[[Category: Taylor ME]]
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[[Category: Weis, W I.]]
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[[Category: Tso CKW]]
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[[Category: Alternative splicing]]
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[[Category: Weis WI]]
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[[Category: Calcium]]
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[[Category: Cell membrane]]
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[[Category: Dc-signr]]
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[[Category: Disulfide bond]]
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[[Category: Endocytosis]]
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[[Category: Four-helix bundle]]
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[[Category: Glycoprotein]]
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[[Category: Host-virus interaction]]
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[[Category: Immune response]]
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[[Category: Lectin]]
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[[Category: Mannose-binding]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Oligomerization domain]]
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[[Category: Polymorphism]]
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[[Category: Receptor]]
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[[Category: Secreted]]
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[[Category: Signal-anchor]]
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[[Category: Sugar binding protein]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 9 14:32:13 2009''
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Current revision

Structure of the neck region of the glycan-binding receptor DC-SIGNR

PDB ID 3jqh

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