3fe0

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{{Seed}}
 
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[[Image:3fe0.jpg|left|200px]]
 
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==X-ray crystal structure of wild type human lysozyme in D2O==
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The line below this paragraph, containing "STRUCTURE_3fe0", creates the "Structure Box" on the page.
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<StructureSection load='3fe0' size='340' side='right'caption='[[3fe0]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fe0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FE0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>
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{{STRUCTURE_3fe0| PDB=3fe0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fe0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fe0 OCA], [https://pdbe.org/3fe0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fe0 RCSB], [https://www.ebi.ac.uk/pdbsum/3fe0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fe0 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN] Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:[https://omim.org/entry/105200 105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.<ref>PMID:8464497</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fe/3fe0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fe0 ConSurf].
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<div style="clear:both"></div>
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===X-ray crystal structure of wild type human lysozyme in D2O===
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==See Also==
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3FE0 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE0 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Lysozyme]]
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[[Category: Large Structures]]
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[[Category: Chatake, T.]]
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[[Category: Chatake T]]
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[[Category: Chiba-Kamoshida, K.]]
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[[Category: Chiba-Kamoshida K]]
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[[Category: Matsui, T.]]
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[[Category: Matsui T]]
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[[Category: Niimura, N.]]
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[[Category: Niimura N]]
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[[Category: Ohhara, T.]]
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[[Category: Ohhara T]]
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[[Category: Ostermann, A.]]
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[[Category: Ostermann A]]
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[[Category: Tanaka, I.]]
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[[Category: Tanaka I]]
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[[Category: Yutani, K.]]
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[[Category: Yutani K]]
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[[Category: Amyloid]]
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[[Category: Amyloidosis]]
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[[Category: Antimicrobial]]
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[[Category: Bacteriolytic enzyme]]
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[[Category: Disease mutation]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase]]
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[[Category: Neutron d2o hydrogen hydration]]
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[[Category: Polymorphism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 9 15:45:04 2009''
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Current revision

X-ray crystal structure of wild type human lysozyme in D2O

PDB ID 3fe0

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