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3hb4

From Proteopedia

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{{Seed}}
 
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[[Image:3hb4.jpg|left|200px]]
 
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<!--
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==17beta-hydroxysteroid dehydrogenase type1 complexed with E2B==
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The line below this paragraph, containing "STRUCTURE_3hb4", creates the "Structure Box" on the page.
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<StructureSection load='3hb4' size='340' side='right'caption='[[3hb4]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3hb4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HB4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E2B:3-{[(9BETA,14BETA,16ALPHA,17ALPHA)-3,17-DIHYDROXYESTRA-1,3,5(10)-TRIEN-16-YL]METHYL}BENZAMIDE'>E2B</scene></td></tr>
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{{STRUCTURE_3hb4| PDB=3hb4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hb4 OCA], [https://pdbe.org/3hb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hb4 RCSB], [https://www.ebi.ac.uk/pdbsum/3hb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hb4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DHB1_HUMAN DHB1_HUMAN] Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hb/3hb4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hb4 ConSurf].
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<div style="clear:both"></div>
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===17beta-hydroxysteroid dehydrogenase type1 complexed with E2B===
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==See Also==
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_19929851}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 19929851 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19929851}}
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==About this Structure==
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3HB4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HB4 OCA].
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==Reference==
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<ref group="xtra">PMID:19929851</ref><references group="xtra"/>
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[[Category: Estradiol 17-beta-dehydrogenase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cadot, C.]]
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[[Category: Large Structures]]
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[[Category: Fournier, D.]]
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[[Category: Cadot C]]
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[[Category: Lin, S X.]]
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[[Category: Fournier D]]
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[[Category: Mazumdar, M.]]
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[[Category: Lin S-X]]
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[[Category: Poirier, D.]]
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[[Category: Mazumdar M]]
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[[Category: Zhu, D W.]]
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[[Category: Poirier D]]
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[[Category: 17betahsd1]]
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[[Category: Zhu D-W]]
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[[Category: Cytoplasm]]
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[[Category: Lipid synthesis]]
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[[Category: Nadp]]
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[[Category: Oxidoreductase]]
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[[Category: Polymorphism]]
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[[Category: Steroid biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 16 13:08:50 2009''
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Current revision

17beta-hydroxysteroid dehydrogenase type1 complexed with E2B

PDB ID 3hb4

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