2wuy

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{{Seed}}
 
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[[Image:2wuy.jpg|left|200px]]
 
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==the crystal structure of wild-type baculovirus polyhedra==
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The line below this paragraph, containing "STRUCTURE_2wuy", creates the "Structure Box" on the page.
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<StructureSection load='2wuy' size='340' side='right'caption='[[2wuy]], [[Resolution|resolution]] 3.09&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wuy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WUY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.09&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wuy OCA], [https://pdbe.org/2wuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wuy RCSB], [https://www.ebi.ac.uk/pdbsum/2wuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wuy ProSAT]</span></td></tr>
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{{STRUCTURE_2wuy| PDB=2wuy | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PYHD_NPVAC PYHD_NPVAC] Major component of the virus occlusion bodies, which are large proteinaceous structures (polyhedra), that protect the virus from the outside environment for extended periods until they are ingested by insect larvae.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wu/2wuy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wuy ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Natural protein crystals (polyhedra) armour certain viruses, allowing them to survive for years under hostile conditions. We have determined the structure of polyhedra of the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV), revealing a highly symmetrical covalently cross-braced robust lattice, the subunits of which possess a flexible adaptor enabling this supra-molecular assembly to specifically entrap massive baculoviruses. Inter-subunit chemical switches modulate the controlled release of virus particles in the unusual high pH environment of the target insect's gut. Surprisingly, the polyhedrin subunits are more similar to picornavirus coat proteins than to the polyhedrin of cytoplasmic polyhedrosis virus (CPV). It is, therefore, remarkable that both AcMNPV and CPV polyhedra possess identical crystal lattices and crystal symmetry. This crystalline arrangement must be particularly well suited to the functional requirements of the polyhedra and has been either preserved or re-selected during evolution. The use of flexible adaptors to generate a powerful system for packaging irregular particles is characteristic of the AcMNPV polyhedrin and may provide a vehicle to sequester a wide range of objects such as biological nano-particles.
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===THE CRYSTAL STRUCTURE OF WILD-TYPE BACULOVIRUS POLYHEDRA===
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How baculovirus polyhedra fit square pegs into round holes to robustly package viruses.,Ji X, Sutton G, Evans G, Axford D, Owen R, Stuart DI EMBO J. 2010 Jan 20;29(2):505-14. Epub 2009 Dec 3. PMID:19959989<ref>PMID:19959989</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2wuy" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19959989}}, adds the Publication Abstract to the page
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*[[Polyhedrin|Polyhedrin]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19959989 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19959989}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2WUY is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Autographa_californica_nucleopolyhedrovirus Autographa californica nucleopolyhedrovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WUY OCA].
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==Reference==
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<ref group="xtra">PMID:19959989</ref><references group="xtra"/>
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[[Category: Autographa californica nucleopolyhedrovirus]]
[[Category: Autographa californica nucleopolyhedrovirus]]
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[[Category: Axford, D.]]
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[[Category: Large Structures]]
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[[Category: Evans, G.]]
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[[Category: Axford D]]
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[[Category: Ji, X.]]
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[[Category: Evans G]]
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[[Category: Owen, R.]]
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[[Category: Ji X]]
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[[Category: Stuart, D.]]
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[[Category: Owen R]]
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[[Category: Sutton, G.]]
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[[Category: Stuart DI]]
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[[Category: Microcrystal]]
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[[Category: Sutton G]]
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[[Category: Polyhedra]]
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[[Category: Viral capsid]]
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[[Category: Viral occlusion body]]
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[[Category: Viral protein]]
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[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 16 13:30:10 2009''
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Current revision

the crystal structure of wild-type baculovirus polyhedra

PDB ID 2wuy

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