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1w61

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[[Image:1w61.png|left|200px]]
 
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==proline racemase in complex with 2 molecules of pyrrole-2-carboxylic acid (holo form)==
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The line below this paragraph, containing "STRUCTURE_1w61", creates the "Structure Box" on the page.
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<StructureSection load='1w61' size='340' side='right'caption='[[1w61]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1w61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W61 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PYC:PYRROLE-2-CARBOXYLATE'>PYC</scene></td></tr>
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{{STRUCTURE_1w61| PDB=1w61 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w61 OCA], [https://pdbe.org/1w61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w61 RCSB], [https://www.ebi.ac.uk/pdbsum/1w61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w61 ProSAT]</span></td></tr>
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</table>
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===PROLINE RACEMASE IN COMPLEX WITH 2 MOLECULES OF PYRROLE-2-CARBOXYLIC ACID (HOLO FORM)===
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== Function ==
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[https://www.uniprot.org/uniprot/PRCMA_TRYCC PRCMA_TRYCC] Catalyzes the interconversion of L- and D-proline. Secreted isoform 1 contributes to parasite immune evasion by acting as a B-cell mitogen. Probably involved in parasite differentiation and infectivity.<ref>PMID:10932226</ref> <ref>PMID:16164548</ref> <ref>PMID:16446443</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16446443 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/1w61_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16446443}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1W61 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W61 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w61 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:16446443</ref><references group="xtra"/>
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<references/>
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[[Category: Proline racemase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
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[[Category: Alzari, P.]]
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[[Category: Alzari P]]
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[[Category: Buschiazzo, A.]]
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[[Category: Buschiazzo A]]
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[[Category: B-cell mitogen,acid/base catalysis,homodimer,alpha/beta domain]]
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[[Category: Racemase pyridoxal phosphate-independent,stereo inversion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Dec 21 15:20:03 2009''
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Current revision

proline racemase in complex with 2 molecules of pyrrole-2-carboxylic acid (holo form)

PDB ID 1w61

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