3h86

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{{Seed}}
 
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[[Image:3h86.png|left|200px]]
 
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==Crystal structure of adenylate kinase from Methanococcus maripaludis==
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The line below this paragraph, containing "STRUCTURE_3h86", creates the "Structure Box" on the page.
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<StructureSection load='3h86' size='340' side='right'caption='[[3h86]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3h86]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanococcus_maripaludis Methanococcus maripaludis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H86 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AP5:BIS(ADENOSINE)-5-PENTAPHOSPHATE'>AP5</scene></td></tr>
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{{STRUCTURE_3h86| PDB=3h86 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h86 OCA], [https://pdbe.org/3h86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h86 RCSB], [https://www.ebi.ac.uk/pdbsum/3h86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h86 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KADA_METMP KADA_METMP]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/3h86_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h86 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the trimeric adenylate kinase from the Archaebacteria Methanococcus mariplaludis (AK(MAR)) has been solved to 2.5-A resolution and the temperature dependent stability and kinetics of the enzyme measured. The K(M) and V(max) of AK(MAR) exhibit only modest temperature dependence from 30 degrees -60 degrees C. Although M. mariplaludis is a mesophile with a maximum growth temperature of 43 degrees C, AK(MAR) has a very broad functional range and stability (T(m) = 74.0 degrees C) that are more consistent with a thermophilic enzyme with high thermostability and exceptional activity over a wide range of temperatures, suggesting that this microbe may have only recently invaded a mesophilic niche and has yet to fully adapt. A comparison of the Local Structural Entropy (LSE) for AK(MAR) to the related adenylate kinases from the mesophile Methanococcus voltae and thermophile Methanococcus thermolithotrophicus show that changes in LSE are able to fully account for the intermediate stability of AK(MAR) and highlights a general mechanism for protein adaptation in this class of enzymes. Proteins 2009. (c) 2009 Wiley-Liss, Inc.
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===Crystal structure of adenylate kinase from Methanococcus maripaludis===
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Crystal structure of a trimeric archaeal adenylate kinase from the mesophile Methanococcus maripaludis with an unusually broad functional range and thermal stability.,Davlieva M, Shamoo Y Proteins. 2009 Jul 20. PMID:19731371<ref>PMID:19731371</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3h86" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19731371}}, adds the Publication Abstract to the page
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*[[Adenylate kinase 3D structures|Adenylate kinase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19731371 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19731371}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3H86 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Methanococcus_maripaludis Methanococcus maripaludis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H86 OCA].
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==Reference==
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<ref group="xtra">PMID:19731371</ref><references group="xtra"/>
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[[Category: Adenylate kinase]]
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[[Category: Methanococcus maripaludis]]
[[Category: Methanococcus maripaludis]]
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[[Category: Milya, D G.]]
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[[Category: Milya DG]]
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[[Category: Yousif,S.]]
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[[Category: Yousif S]]
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[[Category: Adenylate kinase]]
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[[Category: Atp-binding]]
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[[Category: Cytoplasm]]
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[[Category: Kinase]]
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[[Category: Mesophile]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphotransferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 08:53:35 2009''
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Current revision

Crystal structure of adenylate kinase from Methanococcus maripaludis

PDB ID 3h86

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