3k0j

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{{Seed}}
 
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[[Image:3k0j.jpg|left|200px]]
 
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==Crystal structure of the E. coli ThiM riboswitch in complex with thiamine pyrophosphate and the U1A crystallization module==
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The line below this paragraph, containing "STRUCTURE_3k0j", creates the "Structure Box" on the page.
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<StructureSection load='3k0j' size='340' side='right'caption='[[3k0j]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3k0j]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K0J FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
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{{STRUCTURE_3k0j| PDB=3k0j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k0j OCA], [https://pdbe.org/3k0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k0j RCSB], [https://www.ebi.ac.uk/pdbsum/3k0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k0j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/3k0j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k0j ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the E. coli ThiM riboswitch in complex with thiamine pyrophosphate and the U1A crystallization module===
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==See Also==
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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*[[Riboswitch 3D structures|Riboswitch 3D structures]]
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==About this Structure==
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== References ==
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3K0J is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K0J OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:19948769</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Amare, A R.Ferre-D.]]
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[[Category: Large Structures]]
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[[Category: Edwards, T E.]]
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[[Category: Edwards TE]]
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[[Category: Kulshina, N.]]
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[[Category: Ferre-D'Amare AR]]
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[[Category: Acetylation]]
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[[Category: Kulshina N]]
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[[Category: Mrna processing]]
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[[Category: Mrna splicing]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Ribonucleoprotein]]
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[[Category: Riboswitch]]
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[[Category: Rna]]
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[[Category: Rna-binding]]
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[[Category: Rna/rna binding protein complex]]
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[[Category: Spliceosome]]
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[[Category: Thi-box]]
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[[Category: Thim]]
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[[Category: U1a protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 09:53:28 2009''
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Current revision

Crystal structure of the E. coli ThiM riboswitch in complex with thiamine pyrophosphate and the U1A crystallization module

PDB ID 3k0j

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