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2kbk
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:2kbk.jpg|left|200px]] | ||
| - | + | ==Solution Structure of BmK-M10== | |
| - | + | <StructureSection load='2kbk' size='340' side='right'caption='[[2kbk]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2kbk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kbh|2kbh]], [[2kbj|2kbj]]</div></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbk OCA], [https://pdbe.org/2kbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kbk RCSB], [https://www.ebi.ac.uk/pdbsum/2kbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbk ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [[https://www.uniprot.org/uniprot/SCXA_MESMA SCXA_MESMA]] Binds to voltage-dependent sodium channels (Nav) and voltage-dependent delayed rectifier potassium channels and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. Administration to mice at a dosage of 0.8 mg/kg produces an analgesic effect. | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | == | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/2kbk_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kbk ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mesobuthus martensii]] | [[Category: Mesobuthus martensii]] | ||
| - | [[Category: Wu, H | + | [[Category: Wu, H]] |
| - | [[Category: Zhu, J | + | [[Category: Zhu, J]] |
[[Category: Ionic channel inhibitor]] | [[Category: Ionic channel inhibitor]] | ||
[[Category: Neurotoxin]] | [[Category: Neurotoxin]] | ||
| Line 24: | Line 31: | ||
[[Category: Sodium channel inhibitor]] | [[Category: Sodium channel inhibitor]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 09:59:48 2009'' | ||
Current revision
Solution Structure of BmK-M10
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