3i54

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{{Seed}}
 
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[[Image:3i54.png|left|200px]]
 
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==Crystal structure of MtbCRP in complex with cAMP==
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The line below this paragraph, containing "STRUCTURE_3i54", creates the "Structure Box" on the page.
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<StructureSection load='3i54' size='340' side='right'caption='[[3i54]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3i54]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I54 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene></td></tr>
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{{STRUCTURE_3i54| PDB=3i54 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i54 OCA], [https://pdbe.org/3i54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i54 RCSB], [https://www.ebi.ac.uk/pdbsum/3i54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i54 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CRPL_MYCTU CRPL_MYCTU] Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. The CRP regulon is predicted to contain about 115 genes. Some genes are activated by CRP (rpfA, whiB1) while others are repressed (fadD10). There are 2 CRP-binding sites in the promoter of whiB1, at low concentrations of CRP with or without cAMP transcription of whiB1 is enhanced via site CRP1, then repressed as site CRP2 is filled.<ref>PMID:15882420</ref> <ref>PMID:20028978</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/3i54_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i54 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of MtbCRP in complex with cAMP===
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==See Also==
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*[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19740754}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19740754 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_19740754}}
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==About this Structure==
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3I54 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I54 OCA].
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==Reference==
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<ref group="xtra">PMID:19740754</ref><references group="xtra"/>
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Bruning, J B.]]
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[[Category: Bruning JB]]
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[[Category: Palaninathan, S K.]]
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[[Category: Palaninathan SK]]
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[[Category: Reddy, M C.]]
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[[Category: Reddy MC]]
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[[Category: Sacchettini, J C.]]
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[[Category: Sacchettini JC]]
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[[Category: Smith, D.]]
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[[Category: Smith D]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Thurman C]]
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[[Category: Thurman, C.]]
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[[Category: Allosteric mechanism]]
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[[Category: Camp receptor protein]]
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[[Category: Dna binding]]
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[[Category: Dna binding protein]]
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[[Category: Dna-binding]]
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[[Category: Inhibition]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 30 14:15:55 2009''
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Current revision

Crystal structure of MtbCRP in complex with cAMP

PDB ID 3i54

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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