3hxe
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:3hxe.png|left|200px]] | ||
| - | < | + | ==Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 37)== |
| - | + | <StructureSection load='3hxe' size='340' side='right'caption='[[3hxe]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3hxe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HXE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | |
| - | --> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BD8:N-UNDECANOYL-L-HISTIDYL-L-PHENYLALANYL-N-METHYL-N-(2-PYRIDIN-2-YLETHYL)-L-TYROSINAMIDE'>BD8</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hxe OCA], [https://pdbe.org/3hxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hxe RCSB], [https://www.ebi.ac.uk/pdbsum/3hxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hxe ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/3hxe_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hxe ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Geranylgeranyl transferase 3D structures|Geranylgeranyl transferase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
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| - | [[Category: | + | |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Alexandrov | + | [[Category: Alexandrov K]] |
| - | [[Category: Blankenfeldt | + | [[Category: Blankenfeldt W]] |
| - | [[Category: Goody | + | [[Category: Goody RS]] |
| - | [[Category: Guo | + | [[Category: Guo Z]] |
| - | [[Category: Waldmann | + | [[Category: Waldmann H]] |
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Current revision
Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 37)
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