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3hxc

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{{Seed}}
 
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[[Image:3hxc.png|left|200px]]
 
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<!--
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==Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 8)==
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The line below this paragraph, containing "STRUCTURE_3hxc", creates the "Structure Box" on the page.
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<StructureSection load='3hxc' size='340' side='right'caption='[[3hxc]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3hxc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HXC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BD6:N-[(BENZYLOXY)CARBONYL]-L-HISTIDYL-N-METHYL-L-PHENYLALANYL-N-HYDROXY-L-TRYPTOPHANAMIDE'>BD6</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3hxc| PDB=3hxc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hxc OCA], [https://pdbe.org/3hxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hxc RCSB], [https://www.ebi.ac.uk/pdbsum/3hxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hxc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/3hxc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hxc ConSurf].
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<div style="clear:both"></div>
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===Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 8)===
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==See Also==
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*[[Geranylgeranyl transferase 3D structures|Geranylgeranyl transferase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_19894725}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19894725 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19894725}}
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==About this Structure==
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3HXC is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HXC OCA].
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==Reference==
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<ref group="xtra">PMID:19894725</ref><references group="xtra"/>
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[[Category: Protein geranylgeranyltransferase type II]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Alexandrov, K.]]
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[[Category: Alexandrov K]]
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[[Category: Blankenfeldt, W.]]
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[[Category: Blankenfeldt W]]
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[[Category: Goody, R S.]]
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[[Category: Goody RS]]
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[[Category: Guo, Z.]]
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[[Category: Guo Z]]
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[[Category: Waldmann, H.]]
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[[Category: Waldmann H]]
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[[Category: Protein prenylation inhibition]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 30 14:21:04 2009''
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Current revision

Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 8)

PDB ID 3hxc

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