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3iwx

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{{Seed}}
 
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[[Image:3iwx.png|left|200px]]
 
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<!--
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==Crystal structure of cisplatin bound to a human copper chaperone (dimer)==
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The line below this paragraph, containing "STRUCTURE_3iwx", creates the "Structure Box" on the page.
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<StructureSection load='3iwx' size='340' side='right'caption='[[3iwx]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3iwx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IWX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3iwx| PDB=3iwx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwx OCA], [https://pdbe.org/3iwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iwx RCSB], [https://www.ebi.ac.uk/pdbsum/3iwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwx ProSAT]</span></td></tr>
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</table>
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===Crystal structure of cisplatin bound to a human copper chaperone (dimer)===
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== Function ==
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[https://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_19807176}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 19807176 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/3iwx_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_19807176}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3IWX is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWX OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iwx ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:19807176</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boal, A K.]]
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[[Category: Large Structures]]
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[[Category: Rosenzweig, A C.]]
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[[Category: Boal AK]]
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[[Category: Beta-alpha-beta-beta-alpha-beta]]
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[[Category: Rosenzweig AC]]
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[[Category: Chaperone]]
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[[Category: Cisplatin]]
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[[Category: Copper]]
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[[Category: Copper transport]]
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[[Category: Ion transport]]
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[[Category: Metal transport]]
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[[Category: Metal-binding]]
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[[Category: Platinum]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 30 14:35:27 2009''
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Current revision

Crystal structure of cisplatin bound to a human copper chaperone (dimer)

PDB ID 3iwx

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