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3crg

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{{Seed}}
 
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[[Image:3crg.png|left|200px]]
 
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==Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala, Glu82Asn and Lys101Ala==
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The line below this paragraph, containing "STRUCTURE_3crg", creates the "Structure Box" on the page.
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<StructureSection load='3crg' size='340' side='right'caption='[[3crg]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3crg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CRG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3crg| PDB=3crg | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3crg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3crg OCA], [https://pdbe.org/3crg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3crg RCSB], [https://www.ebi.ac.uk/pdbsum/3crg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3crg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/3crg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3crg ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala, Glu82Asn and Lys101Ala===
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==See Also==
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*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19923735}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19923735 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19923735}}
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==About this Structure==
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3CRG is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRG OCA].
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==Reference==
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<ref group="xtra">PMID:19923735</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blaber, M.]]
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[[Category: Large Structures]]
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[[Category: Honjo, E.]]
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[[Category: Blaber M]]
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[[Category: Kuroki, R.]]
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[[Category: Honjo E]]
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[[Category: Lee, J.]]
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[[Category: Kuroki R]]
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[[Category: Meher, A K.]]
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[[Category: Lee J]]
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[[Category: Somasundaram, T.]]
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[[Category: Meher AK]]
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[[Category: Acetylation]]
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[[Category: Somasundaram T]]
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[[Category: Angiogenesis]]
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[[Category: Crystal packing]]
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[[Category: Developmental protein]]
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[[Category: Differentiation]]
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[[Category: Growth factor]]
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[[Category: Heparin-binding]]
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[[Category: Hormone]]
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[[Category: Mitogen]]
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[[Category: Polymorphism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 6 09:04:51 2010''
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Current revision

Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ala, Glu82Asn and Lys101Ala

PDB ID 3crg

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