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2krb

From Proteopedia

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{{Seed}}
 
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[[Image:2krb.jpg|left|200px]]
 
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<!--
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==Solution structure of EIF3B-RRM bound to EIF3J peptide==
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The line below this paragraph, containing "STRUCTURE_2krb", creates the "Structure Box" on the page.
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<StructureSection load='2krb' size='340' side='right'caption='[[2krb]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2krb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KRB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2krb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2krb OCA], [https://pdbe.org/2krb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2krb RCSB], [https://www.ebi.ac.uk/pdbsum/2krb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2krb ProSAT]</span></td></tr>
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{{STRUCTURE_2krb| PDB=2krb | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EIF3B_HUMAN EIF3B_HUMAN] Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.<ref>PMID:9388245</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kr/2krb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2krb ConSurf].
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<div style="clear:both"></div>
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===Solution structure of EIF3B-RRM bound to EIF3J peptide===
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2KRB is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KRB OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Elantak, L.]]
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[[Category: Large Structures]]
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[[Category: Herrmannova, A.]]
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[[Category: Elantak L]]
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[[Category: Janoskova, M.]]
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[[Category: Herrmannova A]]
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[[Category: Lukavsky, P J.]]
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[[Category: Janoskova M]]
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[[Category: Rutkai, E.]]
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[[Category: Lukavsky PJ]]
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[[Category: Valasek, L.]]
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[[Category: Rutkai E]]
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[[Category: Wagner, S.]]
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[[Category: Valasek L]]
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[[Category: Eif3]]
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[[Category: Wagner S]]
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[[Category: Eif3b]]
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[[Category: Eif3j]]
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[[Category: Eukaryotic initiation factor]]
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[[Category: Translation initiation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 6 09:33:07 2010''
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Current revision

Solution structure of EIF3B-RRM bound to EIF3J peptide

PDB ID 2krb

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