2kbh

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{{Seed}}
 
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[[Image:2kbh.png|left|200px]]
 
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==solution structure of BmKalphaTx11 (major conformation)==
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The line below this paragraph, containing "STRUCTURE_2kbh", creates the "Structure Box" on the page.
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<StructureSection load='2kbh' size='340' side='right'caption='[[2kbh]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kbh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KBH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbh OCA], [https://pdbe.org/2kbh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kbh RCSB], [https://www.ebi.ac.uk/pdbsum/2kbh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kbh ProSAT]</span></td></tr>
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{{STRUCTURE_2kbh| PDB=2kbh | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SC11_MESMA SC11_MESMA] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission (By similarity). Shows analgesic activity when intraperitoneally injected into mice.<ref>PMID:22295565</ref> <ref>PMID:21189156</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/2kbh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kbh ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of BmKalphaTx11 presented by this paper is distinctive from any other structures of wide-type scorpion alpha-toxins reported so far, for its trans-9,10 peptide bond conformation is accompanied by 'protruding' topology of the 'NC-domain'. The orientation of the C-tail of BmKalphaTx11 is obviously different from that of classical alpha-toxins (e.g., AaH2, BmK-M8), despite the fact that they share common trans conformation of peptide bond between residues 9 and 10. Accordingly, there must be other structural factors dominating the orientation of the C-tail except the conformation of peptide bond 9-10. Our study reveals that residues at position 58 play an important role in it, and different type of residues at this position (e.g., Lys, Arg, Met, Ile) result in different spatial relationship between the C-terminus and the 'five-residue-turn' and then different topology of the 'NC-domain', therefore residues at position 58 are believed to function as structure and bioactivity switch for specificity of scorpion alpha-toxins. The mechanism for stabilizing the geometry of the 'NC-domain' in wide-type scorpion alpha-toxins is also discussed.
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===solution structure of BmKalphaTx11 (major conformation)===
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Solution structure of BmKalphaTx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch.,Zhu J, Tong X, Cao C, Wu G, Zhang N, Wu H Biochem Biophys Res Commun. 2010 Jan 1;391(1):627-33. Epub 2009 Nov 22. PMID:19932686<ref>PMID:19932686</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19932686}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2kbh" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19932686 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19932686}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2KBH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBH OCA].
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==Reference==
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<ref group="xtra">PMID:19932686</ref><references group="xtra"/>
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[[Category: Mesobuthus martensii]]
[[Category: Mesobuthus martensii]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Zhu, J.]]
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[[Category: Zhu J]]
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[[Category: Ionic channel inhibitor]]
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[[Category: Neurotoxin]]
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[[Category: Protein]]
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[[Category: Secreted]]
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[[Category: Sodium channel inhibitor]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 12:41:02 2010''
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Current revision

solution structure of BmKalphaTx11 (major conformation)

PDB ID 2kbh

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