3a36

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{{Seed}}
 
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[[Image:3a36.jpg|left|200px]]
 
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==Structural insight into the membrane insertion of tail-anchored proteins by Get3==
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The line below this paragraph, containing "STRUCTURE_3a36", creates the "Structure Box" on the page.
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<StructureSection load='3a36' size='340' side='right'caption='[[3a36]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3a36]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A36 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3a36| PDB=3a36 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a36 OCA], [https://pdbe.org/3a36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a36 RCSB], [https://www.ebi.ac.uk/pdbsum/3a36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a36 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GET3_YEAST GET3_YEAST] ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.<ref>PMID:12680698</ref> <ref>PMID:16269340</ref> <ref>PMID:18724936</ref> <ref>PMID:21866104</ref> <ref>PMID:21719644</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/3a36_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a36 ConSurf].
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<div style="clear:both"></div>
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===Structural insight into the membrane insertion of tail-anchored proteins by Get3===
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==See Also==
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*[[ATPase 3D structures|ATPase 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20015340 is the PubMed ID number.
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_20015340}}
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==About this Structure==
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3A36 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A36 OCA].
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==Reference==
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<ref group="xtra">PMID:20015340</ref><references group="xtra"/>
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[[Category: Arsenite-transporting ATPase]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Fukai, S.]]
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[[Category: Fukai S]]
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[[Category: Mimura, H.]]
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[[Category: Mimura H]]
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[[Category: Sato, Y.]]
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[[Category: Sato Y]]
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[[Category: Yamagata, A.]]
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[[Category: Yamagata A]]
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[[Category: Yamashita, M.]]
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[[Category: Yamashita M]]
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[[Category: Yoshikawa, A.]]
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[[Category: Yoshikawa A]]
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[[Category: Arsenical resistance]]
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[[Category: Atp-binding]]
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[[Category: Atpase]]
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[[Category: Cytoplasm]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Er-golgi transport]]
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[[Category: Golgi apparatus]]
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[[Category: Homo dimer]]
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[[Category: Hydrolase]]
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[[Category: Nucleotide-binding]]
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[[Category: Transport]]
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[[Category: Zinc binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 13:53:50 2010''
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Current revision

Structural insight into the membrane insertion of tail-anchored proteins by Get3

PDB ID 3a36

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