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3a6m

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{{Seed}}
 
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[[Image:3a6m.jpg|left|200px]]
 
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==Crystal structure of GrpE from Thermus thermophilus HB8==
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The line below this paragraph, containing "STRUCTURE_3a6m", creates the "Structure Box" on the page.
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<StructureSection load='3a6m' size='340' side='right'caption='[[3a6m]], [[Resolution|resolution]] 3.23&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3a6m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A6M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.23&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a6m OCA], [https://pdbe.org/3a6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a6m RCSB], [https://www.ebi.ac.uk/pdbsum/3a6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a6m ProSAT]</span></td></tr>
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{{STRUCTURE_3a6m| PDB=3a6m | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of GrpE from Thermus thermophilus HB8===
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[https://www.uniprot.org/uniprot/GRPE_THET8 GRPE_THET8] Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 20036249 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a6/3a6m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_20036249}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a6m ConSurf].
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3A6M is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus_hb8 Thermus thermophilus hb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A6M OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:20036249</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Thermus thermophilus hb8]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Miki, K.]]
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[[Category: Miki K]]
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[[Category: Nakamura, A.]]
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[[Category: Nakamura A]]
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[[Category: Takumi, K.]]
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[[Category: Takumi K]]
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[[Category: Chaperone]]
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[[Category: Coiled-coil]]
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[[Category: Cytoplasm]]
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[[Category: Dimer]]
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[[Category: Four-helix bundle]]
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[[Category: Grpe]]
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[[Category: Stress response]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 14:11:39 2010''
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Current revision

Crystal structure of GrpE from Thermus thermophilus HB8

PDB ID 3a6m

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