1z14

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(New page: 200px<br /><applet load="1z14" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z14, resolution 3.25&Aring;" /> '''Structural Determina...)
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[[Image:1z14.gif|left|200px]]<br /><applet load="1z14" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1z14, resolution 3.25&Aring;" />
 
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'''Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute Virus of Mice'''<br />
 
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==Overview==
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==Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute Virus of Mice==
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Two strains of the parvovirus minute virus of mice (MVM), the, immunosuppressive (MVMi) and the prototype (MVMp) strains, display, disparate in vitro tropism and in vivo pathogenicity. We report the, crystal structures of MVMp virus-like particles (MVMp(b)) and native, wild-type (wt) empty capsids (MVMp(e)), determined and refined to 3.25 and, 3.75 A resolution, respectively, and their comparison to the structure of, MVMi, also refined to 3.5 A resolution in this study. A comparison of the, MVMp(b) and MVMp(e) capsids showed their structures to be the same, providing structural verification that some heterologously expressed, parvovirus capsids are indistinguishable from wt capsids produced in host, cells. The structures of MVMi and MVMp capsids were almost identical, but, local surface conformational differences clustered from symmetry-related, capsid proteins at three specific domains: (i) the icosahedral fivefold, axis, (ii) the "shoulder" of the protrusion at the icosahedral threefold, axis, and (iii) the area surrounding the depression at the icosahedral, twofold axis. The latter two domains contain important determinants of MVM, in vitro tropism (residues 317 and 321) and forward mutation residues, (residues 399, 460, 553, and 558) conferring fibrotropism on MVMi., Furthermore, these structural differences between the MVM strains, colocalize with tropism and pathogenicity determinants mapped for other, autonomous parvovirus capsids, highlighting the importance of common, parvovirus capsid regions in the control of virus-host interactions.
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<StructureSection load='1z14' size='340' side='right'caption='[[1z14]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1z14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Minute_virus_of_mice Minute virus of mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z14 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z14 OCA], [https://pdbe.org/1z14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z14 RCSB], [https://www.ebi.ac.uk/pdbsum/1z14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z14 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q84367_MUMIP Q84367_MUMIP]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z1/1z14_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z14 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1Z14 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Minute_virus_of_mice Minute virus of mice]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Z14 OCA].
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice., Kontou M, Govindasamy L, Nam HJ, Bryant N, Llamas-Saiz AL, Foces-Foces C, Hernando E, Rubio MP, McKenna R, Almendral JM, Agbandje-McKenna M, J Virol. 2005 Sep;79(17):10931-43. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16103145 16103145]
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[[Category: Large Structures]]
[[Category: Minute virus of mice]]
[[Category: Minute virus of mice]]
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[[Category: Single protein]]
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[[Category: Agbandje-McKenna M]]
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[[Category: Agbandje-McKenna, M.]]
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[[Category: Almendral JM]]
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[[Category: Almendral, J.M.]]
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[[Category: Bryant N]]
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[[Category: Bryant, N.]]
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[[Category: Foces-Foces C]]
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[[Category: Foces-Foces, C.]]
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[[Category: Govindasamy L]]
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[[Category: Govindasamy, L.]]
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[[Category: Hernando E]]
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[[Category: Hernando, E.]]
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[[Category: Kontou M]]
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[[Category: Kontou, M.]]
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[[Category: Llamas-Saiz AL]]
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[[Category: Llamas-Saiz, A.L.]]
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[[Category: McKenna R]]
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[[Category: McKenna, R.]]
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[[Category: Nam HJ]]
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[[Category: Nam, H.J.]]
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[[Category: Rubio MP]]
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[[Category: Rubio, M.P.]]
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[[Category: icosahedral virus]]
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[[Category: minute virus of mice]]
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[[Category: prototype strain]]
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[[Category: x-ray crystallography]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 04:41:34 2007''
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Current revision

Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute Virus of Mice

PDB ID 1z14

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