3jtg

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{{Seed}}
 
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[[Image:3jtg.jpg|left|200px]]
 
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==Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA==
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The line below this paragraph, containing "STRUCTURE_3jtg", creates the "Structure Box" on the page.
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<StructureSection load='3jtg' size='340' side='right'caption='[[3jtg]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3jtg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JTG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jtg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jtg OCA], [https://pdbe.org/3jtg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jtg RCSB], [https://www.ebi.ac.uk/pdbsum/3jtg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jtg ProSAT]</span></td></tr>
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{{STRUCTURE_3jtg| PDB=3jtg | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA===
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[https://www.uniprot.org/uniprot/ELF3_MOUSE ELF3_MOUSE] Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter (By similarity). Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity (By similarity). Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway (By similarity). May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.<ref>PMID:9806763</ref> <ref>PMID:11984530</ref> <ref>PMID:11893733</ref> <ref>PMID:16630543</ref> <ref>PMID:9395241</ref> <ref>PMID:11025204</ref> <ref>PMID:16141072</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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3JTG is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JTG OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/3jtg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jtg ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Agarkar, V B.]]
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[[Category: Agarkar VB]]
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[[Category: Babayeva, N D.]]
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[[Category: Babayeva ND]]
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[[Category: Rizzino, A.]]
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[[Category: Rizzino A]]
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[[Category: Tahirov, T H.]]
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[[Category: Tahirov TH]]
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[[Category: Activator]]
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[[Category: Alternative splicing]]
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[[Category: Cytoplasm]]
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[[Category: Developmental protein]]
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[[Category: Differentiation]]
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[[Category: Dna-binding]]
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[[Category: Elf3]]
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[[Category: Inflammatory response]]
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[[Category: Nucleus]]
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[[Category: Protein-dna complex]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Type ii tgf-beta receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 14:30:10 2010''
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Current revision

Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA

PDB ID 3jtg

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OCA

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