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1z47

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Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius

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Retrieved from "http://52.214.119.220/wiki/index.php/1z47"

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-[[Image:1z47.gif|left|200px]]<br /><applet load="1z47" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1z47, resolution 1.90&Aring;" />
-'''Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius'''<br />
-==Overview==
+==Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius==
-CysA, the ATPase subunit of a putative sulfate ATP-binding cassette, transport system of the gram-positive thermoacidophilic bacterium, Alicyclobacillus acidocaldarius, was structurally characterized at a, resolution of 2.0 Angstroms in the absence of nucleotides. In line with, previous findings on ABC-ATPases the structures of the two monomers, (called CysA-1 and CysA-2) in the asymmetric unit differ substantially in, the arrangement of their individual (sub)domains. CysA-2 was found as a, physiological dimer composed of two crystallographically related monomers, that are arranged in an open state. Interestingly, while the regulatory, domain of CysA-2 packs against its opposing domain that of CysA-1, undergoes a conformational change and, in the dimer, would interfere with, the opposing monomer thereby preventing solute translocation. Whether this, conformational state is used for regulatory purposes will be discussed.
+<StructureSection load='1z47' size='340' side='right'caption='[[1z47]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1z47]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z47 FirstGlance]. <br>
-Z47 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius] with CL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Z47 OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-==Reference==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z47 OCA], [https://pdbe.org/1z47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z47 RCSB], [https://www.ebi.ac.uk/pdbsum/1z47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z47 ProSAT]</span></td></tr>
-Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius., Scheffel F, Demmer U, Warkentin E, Hulsmann A, Schneider E, Ermler U, FEBS Lett. 2005 May 23;579(13):2953-8. Epub 2005 Apr 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15893314 15893314]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q9RHZ7_ALIAC Q9RHZ7_ALIAC]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z4/1z47_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z47 ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Alicyclobacillus acidocaldarius]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Demmer, U.]]
+[[Category: Demmer U]]
-[[Category: Ermler, U.]]
+[[Category: Ermler U]]
-[[Category: Huelsmann, A.]]
+[[Category: Huelsmann A]]
-[[Category: Scheffel, F.]]
+[[Category: Scheffel F]]
-[[Category: Schneider, E.]]
+[[Category: Schneider E]]
-[[Category: Warkentin, E.]]
+[[Category: Warkentin E]]
-[[Category: CL]]
-[[Category: alpha/beta motif; beta sandwich]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 04:44:08 2007''

1z47

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Structure of the ATPase subunit CysA of the putative sulfate ATP-binding cassette (ABC) transporter from Alicyclobacillus acidocaldarius

Structural highlights

Function

Evolutionary Conservation

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