1z77
From Proteopedia
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(New page: 200px<br /><applet load="1z77" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z77, resolution 2.00Å" /> '''Crystal structure of...) |
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| - | [[Image:1z77.gif|left|200px]]<br /><applet load="1z77" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1z77, resolution 2.00Å" /> | ||
| - | '''Crystal structure of transcriptional regulator protein from Thermotoga maritima.'''<br /> | ||
| - | == | + | ==Crystal structure of transcriptional regulator protein from Thermotoga maritima.== |
| - | The crystal structure of a putative transcriptional regulator protein | + | <StructureSection load='1z77' size='340' side='right'caption='[[1z77]], [[Resolution|resolution]] 2.00Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1z77]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z77 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z77 OCA], [https://pdbe.org/1z77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z77 RCSB], [https://www.ebi.ac.uk/pdbsum/1z77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z77 ProSAT], [https://www.topsan.org/Proteins/MCSG/1z77 TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9X0C0_THEMA Q9X0C0_THEMA] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z7/1z77_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z77 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The crystal structure of a putative transcriptional regulator protein TM1030 from Thermotoga maritima, a hyperthermophilic bacterium, was determined by an unusual multi-wavelength anomalous dispersion method at 2.0 A resolution, in which data from two different crystals and two different beamlines were used. The protein belongs to the tetracycline repressor TetR superfamily. The three-dimensional structure of TM1030 is similar to the structures of proteins that function as multidrug-binding transcriptional repressors, and contains a large solvent-exposed pocket similar to the drug-binding pockets present in those repressors. The asymmetric unit in the crystal structure contains a single protein chain and the twofold symmetry of the dimer is adopted by the crystal symmetry. The structure described in this paper is an apo- form of TM1030. Although it is known that the protein is significantly overexpressed during heat shock, its detailed function cannot be yet explained. | ||
| - | + | Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment.,Koclega KD, Chruszcz M, Zimmerman MD, Cymborowski M, Evdokimova E, Minor W J Struct Biol. 2007 Sep;159(3):424-32. Epub 2007 May 16. PMID:17588774<ref>PMID:17588774</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1z77" style="background-color:#fffaf0;"></div> | |
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| - | + | ==See Also== | |
| + | *[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]] | ||
| + | *[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Thermotoga maritima]] | ||
| + | [[Category: Chruszcz M]] | ||
| + | [[Category: Cymborowski M]] | ||
| + | [[Category: Koclega KD]] | ||
| + | [[Category: Kudritska M]] | ||
| + | [[Category: Minor W]] | ||
| + | [[Category: Zimmerman MD]] | ||
Current revision
Crystal structure of transcriptional regulator protein from Thermotoga maritima.
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