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2wqk
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:2wqk.png|left|200px]] | ||
| - | < | + | ==Crystal Structure of Sure Protein from Aquifex aeolicus== |
| - | + | <StructureSection load='2wqk' size='340' side='right'caption='[[2wqk]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2wqk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2phj 2phj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |
| - | - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqk OCA], [https://pdbe.org/2wqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wqk RCSB], [https://www.ebi.ac.uk/pdbsum/2wqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqk ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SURE_AQUAE SURE_AQUAE] Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wq/2wqk_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wqk ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | SurE is a stationary-phase survival protein found in bacteria, eukaryotes and archaea that exhibits a divalent-metal-ion-dependent phosphatase activity and acts as a nucleotidase and polyphosphate phosphohydrolase. The structure of the SurE protein from the hyperthermophile Aquifex aeolicus has been solved at 1.5 A resolution using molecular replacement with one dimer in the asymmetric unit and refined to an R factor of 15.6%. The crystal packing reveals that two dimers assemble to form a tetramer, although gel-filtration chromatography showed the presence of only a dimer in solution. The phosphatase active-site pocket was occupied by sulfate ions from the crystallization medium. | ||
| - | + | Structure of SurE protein from Aquifex aeolicus VF5 at 1.5 A resolution.,Antonyuk SV, Ellis MJ, Strange RW, Bessho Y, Kuramitsu S, Shinkai A, Yokoyama S, Hasnain SS Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt, 12):1204-8. Epub 2009 Nov 27. PMID:20054112<ref>PMID:20054112</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2wqk" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | == | + | [[Category: Aquifex aeolicus VF5]] |
| - | + | [[Category: Large Structures]] | |
| - | + | [[Category: Antonyuk SV]] | |
| - | == | + | [[Category: Bessho Y]] |
| - | < | + | [[Category: Ellis MJ]] |
| - | [[Category: | + | [[Category: Hasnain SS]] |
| - | [[Category: | + | [[Category: Kuramitsu S]] |
| - | [[Category: Antonyuk | + | [[Category: Strange RW]] |
| - | [[Category: Bessho | + | [[Category: Yokoyama S]] |
| - | [[Category: Ellis | + | |
| - | [[Category: Hasnain | + | |
| - | [[Category: Kuramitsu | + | |
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| - | [[Category: Strange | + | |
| - | [[Category: Yokoyama | + | |
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Current revision
Crystal Structure of Sure Protein from Aquifex aeolicus
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