2kit

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{{Seed}}
 
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[[Image:2kit.jpg|left|200px]]
 
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==The solution structure of the reduced yeast TOR1 FATC domain bound to DPC micelles at 298K==
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The line below this paragraph, containing "STRUCTURE_2kit", creates the "Structure Box" on the page.
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<StructureSection load='2kit' size='340' side='right'caption='[[2kit]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kit]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KIT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kit OCA], [https://pdbe.org/2kit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kit RCSB], [https://www.ebi.ac.uk/pdbsum/2kit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kit ProSAT]</span></td></tr>
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{{STRUCTURE_2kit| PDB=2kit | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TOR1_YEAST TOR1_YEAST] Phosphatidylinositol 3-kinase homolog, component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. TORC1 controls many of these processes via TIP41-TAP42-mediated inhibition of the type 2A-related phosphatases PP2A and SIT4.<ref>PMID:7606777</ref> <ref>PMID:8741837</ref> <ref>PMID:9843498</ref> <ref>PMID:9539725</ref> <ref>PMID:10329624</ref> <ref>PMID:10198052</ref> <ref>PMID:10604478</ref> <ref>PMID:10995454</ref> <ref>PMID:11741537</ref> <ref>PMID:15620355</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/2kit_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kit ConSurf].
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<div style="clear:both"></div>
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===The solution struture of the reduced yeast TOR1 FATC domain bound to DPC micelles at 298K===
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20042596 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_20042596}}
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==About this Structure==
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2KIT is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIT OCA].
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==Reference==
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<ref group="xtra">PMID:20042596</ref><references group="xtra"/>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Dames, S A.]]
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[[Category: Dames SA]]
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[[Category: Atp-binding]]
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[[Category: Cell cycle]]
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[[Category: Cell membrane]]
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[[Category: Dpc micelle]]
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[[Category: Kinase]]
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[[Category: Membrane]]
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[[Category: Membrane-mimetic]]
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[[Category: Nucleotide-binding]]
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[[Category: Protein]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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[[Category: Vacuole]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 15:06:48 2010''
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Current revision

The solution structure of the reduced yeast TOR1 FATC domain bound to DPC micelles at 298K

PDB ID 2kit

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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