2kp8

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{{Seed}}
 
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[[Image:2kp8.jpg|left|200px]]
 
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==Ligand bound to a model peptide that mimics the open fusogenic form==
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The line below this paragraph, containing "STRUCTURE_2kp8", creates the "Structure Box" on the page.
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<StructureSection load='2kp8' size='340' side='right'caption='[[2kp8]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kp8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KP8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XIG:5-{[(4-METHOXYBIPHENYL-4-YL)METHYL][(1S)-1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL]CARBAMOYL}BENZENE-1,2,4-TRICARBOXYLIC+ACID'>XIG</scene></td></tr>
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{{STRUCTURE_2kp8| PDB=2kp8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kp8 OCA], [https://pdbe.org/2kp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kp8 RCSB], [https://www.ebi.ac.uk/pdbsum/2kp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kp8 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The ectodomain of HIV-1 gp41 mediates the fusion of viral and host cellular membranes. The peptide-based drug Enfuvirtide(1) is precedent that antagonists of this fusion activity may act as anti HIV-agents. Here, NMR screening was used to discover non-peptide leads against this target and resulted in the discovery of a new benzamide 1 series. This series is non-peptide, low molecular weight, and analogs have activity in a cell fusion assay with EC50 values ranging 3-41microM. Structural work on the gp41/benzamide 1 complex was determined by NMR spectroscopy using a designed model peptide system that mimics an open pocket of the fusogenic form of the protein.
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===Ligand bound to a model peptide that mimics the open fusogenic form===
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Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket.,Stewart KD, Huth JR, Ng TI, McDaniel K, Hutchinson RN, Stoll VS, Mendoza RR, Matayoshi ED, Carrick R, Mo H, Severin J, Walter K, Richardson PL, Barrett LW, Meadows R, Anderson S, Kohlbrenner W, Maring C, Kempf DJ, Molla A, Olejniczak ET Bioorg Med Chem Lett. 2010 Jan 15;20(2):612-7. Epub 2009 Nov 20. PMID:20004576<ref>PMID:20004576</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20004576}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2kp8" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20004576 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20004576}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2KP8 is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KP8 OCA].
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==Reference==
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<ref group="xtra">PMID:20004576</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Olejniczak, E T.]]
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[[Category: Large Structures]]
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[[Category: Protein/ligand]]
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[[Category: Olejniczak ET]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 15:07:17 2010''
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Current revision

Ligand bound to a model peptide that mimics the open fusogenic form

PDB ID 2kp8

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