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3k7m

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{{Seed}}
 
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[[Image:3k7m.jpg|left|200px]]
 
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==Crystal structure of 6-hydroxy-L-nicotine oxidase from Arthrobacter nicotinovorans==
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The line below this paragraph, containing "STRUCTURE_3k7m", creates the "Structure Box" on the page.
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<StructureSection load='3k7m' size='340' side='right'caption='[[3k7m]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3k7m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Paenarthrobacter_nicotinovorans Paenarthrobacter nicotinovorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K7M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GP7:(1R)-2-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTADECANOYLOXY)METHYL]ETHYL+(12E)-HEXADECA-9,12-DIENOATE'>GP7</scene></td></tr>
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{{STRUCTURE_3k7m| PDB=3k7m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k7m OCA], [https://pdbe.org/3k7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k7m RCSB], [https://www.ebi.ac.uk/pdbsum/3k7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k7m ProSAT]</span></td></tr>
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</table>
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===Crystal structure of 6-hydroxy-L-nicotine oxidase from Arthrobacter nicotinovorans===
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== Function ==
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[https://www.uniprot.org/uniprot/HLNO_PAENI HLNO_PAENI] Involved in the degradation of L-nicotine (PubMed:5849820). Catalyzes the oxidation of (S)-6-hydroxynicotine (6-hydroxy-L-nicotine) to 6-hydroxypseudooxynicotine (PubMed:5849820, PubMed:4965794, PubMed:5646150, PubMed:21383134, PubMed:26744768, PubMed:28080034). Oxidation of the pyrrolidine ring of (S)-6-hydroxynicotine leads to the formation of the optically inactive 6-hydroxy-N-methylmyosmine, which hydrolyzes spontaneously to 6-hydroxypseudooxynicotine (PubMed:4965794, PubMed:21383134, PubMed:26744768, PubMed:28080034). Acts with absolute stereospecificity on the L-form of 6-hydroxynicotine (PubMed:4965794). Can also use (S)-6-hydroxynornicotine (PubMed:26744768, PubMed:28080034).<ref>PMID:21383134</ref> <ref>PMID:26744768</ref> <ref>PMID:28080034</ref> <ref>PMID:4965794</ref> <ref>PMID:5646150</ref> <ref>PMID:5849820</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 20006620 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/3k7m_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_20006620}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3K7M is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arthrobacter_nicotinovorans Arthrobacter nicotinovorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K7M OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k7m ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:20006620</ref><references group="xtra"/>
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<references/>
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[[Category: Arthrobacter nicotinovorans]]
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__TOC__
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[[Category: Bartunik, H D.]]
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</StructureSection>
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[[Category: Bourenkov, G P.]]
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[[Category: Large Structures]]
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[[Category: Kachalova, G S]]
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[[Category: Paenarthrobacter nicotinovorans]]
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[[Category: Enantiomeric substrate]]
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[[Category: Bartunik HD]]
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[[Category: Flavoenzyme]]
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[[Category: Bourenkov GP]]
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[[Category: Nicotine degradation]]
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[[Category: Kachalova GS]]
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[[Category: Oxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 15:56:15 2010''
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Current revision

Crystal structure of 6-hydroxy-L-nicotine oxidase from Arthrobacter nicotinovorans

PDB ID 3k7m

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