3kg7

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{{Seed}}
 
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[[Image:3kg7.jpg|left|200px]]
 
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==Dehydratase domain from CurH module of Curacin polyketide synthase==
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The line below this paragraph, containing "STRUCTURE_3kg7", creates the "Structure Box" on the page.
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<StructureSection load='3kg7' size='340' side='right'caption='[[3kg7]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kg7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lyngbya_majuscula Lyngbya majuscula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KG7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3kg7| PDB=3kg7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kg7 OCA], [https://pdbe.org/3kg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kg7 RCSB], [https://www.ebi.ac.uk/pdbsum/3kg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kg7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q6DNE5_9CYAN Q6DNE5_9CYAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/3kg7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kg7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Modular polyketide synthases (PKS) make novel natural products through a series of preprogrammed chemical steps catalyzed by an assembly line of multidomain modules. Each assembly-line step involves unique extension and modification reactions, resulting in tremendous diversity of polyketide products. Dehydratase domains catalyze formation of an alpha,beta-double bond in the nascent polyketide intermediate. We present crystal structures of the four dehydratase domains from the curacin A PKS. The catalytic residues and substrate binding site reside in a tunnel within a single monomer. The positions of the catalytic residues and shape of the substrate tunnel explain how chirality of the substrate hydroxyl group may determine the configuration of the product double bond. Access to the active site may require opening the substrate tunnel, forming an open trench. The arrangement of monomers within the dimer is consistent among PKS dehydratases and differs from that seen in the related mammalian fatty acid synthases.
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===Dehydratase domain from CurH module of Curacin polyketide synthase===
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Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.,Akey DL, Razelun JR, Tehranisa J, Sherman DH, Gerwick WH, Smith JL Structure. 2010 Jan 13;18(1):94-105. PMID:20152156<ref>PMID:20152156</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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3KG7 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Lyngbya_majuscula Lyngbya majuscula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KG7 OCA].
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<div class="pdbe-citations 3kg7" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Lyngbya majuscula]]
[[Category: Lyngbya majuscula]]
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[[Category: Akey, D L.]]
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[[Category: Akey DL]]
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[[Category: Smith, J L.]]
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[[Category: Smith JL]]
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[[Category: Dehydratase]]
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[[Category: Double hotdog fold]]
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[[Category: Polyketide synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 15:57:34 2010''
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Current revision

Dehydratase domain from CurH module of Curacin polyketide synthase

PDB ID 3kg7

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