3bim

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{{Seed}}
 
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[[Image:3bim.png|left|200px]]
 
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==Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide==
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The line below this paragraph, containing "STRUCTURE_3bim", creates the "Structure Box" on the page.
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<StructureSection load='3bim' size='340' side='right'caption='[[3bim]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bim]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BIM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bim OCA], [https://pdbe.org/3bim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bim RCSB], [https://www.ebi.ac.uk/pdbsum/3bim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bim ProSAT]</span></td></tr>
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{{STRUCTURE_3bim| PDB=3bim | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
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== Function ==
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[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/3bim_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bim ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The transcriptional corepressors BCOR, SMRT, and NCoR are known to bind competitively to the BCL6 BTB domain despite the fact that BCOR has no detectable sequence similarity to the other two corepressors. We have identified a 17 residue motif from BCOR that binds directly to the BCL6 BTB domain and determined the crystal structure of the complex to a resolution of 2.6 A. Remarkably, the BCOR BCL6 binding domain (BCOR(BBD)) peptide binds in the same BCL6 binding site as the SMRT(BBD) peptide despite the lack of any significant sequence similarity between the two peptides. Mutations of critical BCOR(BBD) residues cause the disruption of the BCL6 corepression activities of BCOR, and a BCOR(BBD) peptide blocks BCL6-mediated transcriptional repression and kills lymphoma cells.
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===Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide===
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Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.,Ghetu AF, Corcoran CM, Cerchietti L, Bardwell VJ, Melnick A, Prive GG Mol Cell. 2008 Feb 15;29(3):384-91. PMID:18280243<ref>PMID:18280243</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3bim" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18280243}}, adds the Publication Abstract to the page
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18280243 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18280243}}
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__TOC__
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</StructureSection>
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==Disease==
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Known disease associated with this structure: Microphthalmia, syndromic 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300485 300485]]
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==About this Structure==
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3BIM is a 16 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BIM OCA].
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==Reference==
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<ref group="xtra">PMID:18280243</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ghetu, A F.]]
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[[Category: Large Structures]]
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[[Category: Prive, G G.]]
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[[Category: Ghetu AF]]
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[[Category: Activator]]
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[[Category: Prive GG]]
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[[Category: Alternative splicing]]
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[[Category: Ank repeat]]
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[[Category: Chromatin regulator]]
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[[Category: Chromosomal rearrangement]]
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[[Category: Disease mutation]]
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[[Category: Dna-binding]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Protein-peptide compex]]
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[[Category: Proto-oncogene]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription repressor]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 16:23:02 2010''
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Current revision

Crystal structure of the BCL6 BTB domain dimer in complex with the BCOR BBD corepressor peptide

PDB ID 3bim

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