3i8c

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{{Seed}}
 
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[[Image:3i8c.png|left|200px]]
 
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==Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR21A==
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The line below this paragraph, containing "STRUCTURE_3i8c", creates the "Structure Box" on the page.
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<StructureSection load='3i8c' size='340' side='right'caption='[[3i8c]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3i8c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I8C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i8c OCA], [https://pdbe.org/3i8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i8c RCSB], [https://www.ebi.ac.uk/pdbsum/3i8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i8c ProSAT]</span></td></tr>
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{{STRUCTURE_3i8c| PDB=3i8c | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DCAF4_HUMAN DCAF4_HUMAN] May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.<ref>PMID:16949367</ref> <ref>PMID:16964240</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i8/3i8c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i8c ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The cullin 4-DNA-damage-binding protein 1 (CUL4-DDB1) ubiquitin ligase machinery regulates diverse cellular functions and can be subverted by pathogenic viruses. Here we report the crystal structure of DDB1 in complex with a central fragment of hepatitis B virus X protein (HBx), whose DDB1-binding activity is important for viral infection. The structure reveals that HBx binds DDB1 through an alpha-helical motif, which is also found in the unrelated paramyxovirus SV5-V protein despite their sequence divergence. Our structure-based functional analysis suggests that, like SV5-V, HBx captures DDB1 to redirect the ubiquitin ligase activity of the CUL4-DDB1 E3 ligase. We also identify the alpha-helical motif shared by these viral proteins in the cellular substrate-recruiting subunits of the E3 complex, the DDB1-CUL4-associated factors (DCAFs) that are functionally mimicked by the viral hijackers. Together, our studies reveal a common yet promiscuous structural element that is important for the assembly of cellular and virally hijacked CUL4-DDB1 E3 complexes.
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===Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR21A===
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A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.,Li T, Robert EI, van Breugel PC, Strubin M, Zheng N Nat Struct Mol Biol. 2010 Jan;17(1):105-11. Epub 2009 Dec 6. PMID:19966799<ref>PMID:19966799</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3i8c" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19966799}}, adds the Publication Abstract to the page
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*[[DNA damage-binding protein|DNA damage-binding protein]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19966799 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19966799}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3I8C is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I8C OCA].
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==Reference==
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<ref group="xtra">PMID:19966799</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Breugel, P C.V.]]
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[[Category: Large Structures]]
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[[Category: Li, T.]]
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[[Category: Breugel PCV]]
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[[Category: Robert, E I.]]
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[[Category: Li T]]
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[[Category: Strubin, M.]]
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[[Category: Robert EI]]
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[[Category: Zheng, N.]]
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[[Category: Strubin M]]
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[[Category: Alternative splicing]]
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[[Category: Zheng N]]
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[[Category: Cytoplasm]]
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[[Category: Dcaf4]]
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[[Category: Ddb1]]
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[[Category: Dna damage]]
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[[Category: Dna repair]]
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[[Category: Dna-binding]]
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[[Category: H-box motif]]
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[[Category: Host-virus interaction]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Ubl conjugation]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Wd repeat]]
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[[Category: Wdr21a]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 15:31:12 2010''
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Current revision

Crystal Structure of DDB1 in Complex with the H-Box Motif of WDR21A

PDB ID 3i8c

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OCA

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