2kr9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Kalirin DH1 NMR structure== | |
| - | + | <StructureSection load='2kr9' size='340' side='right'caption='[[2kr9]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2kr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KR9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kr9 OCA], [https://pdbe.org/2kr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kr9 RCSB], [https://www.ebi.ac.uk/pdbsum/2kr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kr9 ProSAT]</span></td></tr> | |
| - | '' | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KALRN_RAT KALRN_RAT] Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation.<ref>PMID:10692441</ref> <ref>PMID:11606631</ref> <ref>PMID:15950621</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Gorbatyuk VY]] | ||
| + | [[Category: Hoch JC]] | ||
| + | [[Category: Schiller MR]] | ||
Current revision
Kalirin DH1 NMR structure
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