2x2s
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2x2s is ON HOLD until Paper Publication Authors: Sulzenbacher, G., Roig-Zamboni, V., Peumans, W.J., Rouge, P., Van Damme, E.J.M., Bourne, Y. Descri...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Sclerotinia sclerotiorum agglutinin SSA== | |
| + | <StructureSection load='2x2s' size='340' side='right'caption='[[2x2s]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2x2s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sclerotinia_sclerotiorum Sclerotinia sclerotiorum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X2S FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2s OCA], [https://pdbe.org/2x2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x2s RCSB], [https://www.ebi.ac.uk/pdbsum/2x2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x2s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AGGL_SCLSC AGGL_SCLSC] Lectin that primarily recognizes glycans with a non-reducing terminal N-acetylgalactosamine (GalNAc), with a preference for the alpha- over the beta-anomer. Can also bind non-reducing terminal galactose (Gal) residues but with a lower affinity. Strongly interacts with glycolipid type glycans with terminal non-reducing Gal or GalNAc but fails to bind sialylated or fucosylated forms of the same glycans. Strongly interacts with galactosylated N-glycans, displaying highest affinity for alpha-1-3 branched mono-antennary N-glycans but also binding to multi-antennary glycans.<ref>PMID:12901882</ref> <ref>PMID:17294128</ref> <ref>PMID:20566411</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/2x2s_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x2s ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Agglutinin 3D structures|Agglutinin 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sclerotinia sclerotiorum]] | ||
| + | [[Category: Bourne Y]] | ||
| + | [[Category: Peumans WJ]] | ||
| + | [[Category: Roig-Zamboni V]] | ||
| + | [[Category: Rouge P]] | ||
| + | [[Category: Sulzenbacher G]] | ||
| + | [[Category: Van Damme EJM]] | ||
Current revision
Crystal structure of Sclerotinia sclerotiorum agglutinin SSA
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