3iab

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{{Seed}}
 
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[[Image:3iab.jpg|left|200px]]
 
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==Crystal structure of RNase P /RNase MRP proteins Pop6, Pop7 in a complex with the P3 domain of RNase MRP RNA==
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The line below this paragraph, containing "STRUCTURE_3iab", creates the "Structure Box" on the page.
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<StructureSection load='3iab' size='340' side='right'caption='[[3iab]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3iab]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IAB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3iab| PDB=3iab | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iab OCA], [https://pdbe.org/3iab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iab RCSB], [https://www.ebi.ac.uk/pdbsum/3iab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iab ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POP6_YEAST POP6_YEAST] Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.<ref>PMID:9620854</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3iab_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iab ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ribonuclease (RNase) P is a site-specific endoribonuclease found in all kingdoms of life. Typical RNase P consists of a catalytic RNA component and a protein moiety. In the eukaryotes, the RNase P lineage has split into two, giving rise to a closely related enzyme, RNase MRP, which has similar components but has evolved to have different specificities. The eukaryotic RNases P/MRP have acquired an essential helix-loop-helix protein-binding RNA domain P3 that has an important function in eukaryotic enzymes and distinguishes them from bacterial and archaeal RNases P. Here, we present a crystal structure of the P3 RNA domain from Saccharomyces cerevisiae RNase MRP in a complex with RNase P/MRP proteins Pop6 and Pop7 solved to 2.7 A. The structure suggests similar structural organization of the P3 RNA domains in RNases P/MRP and possible functions of the P3 domains and proteins bound to them in the stabilization of the holoenzymes' structures as well as in interactions with substrates. It provides the first insight into the structural organization of the eukaryotic enzymes of the RNase P/MRP family.
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===Crystal structure of RNase P /RNase MRP proteins Pop6, Pop7 in a complex with the P3 domain of RNase MRP RNA===
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Eukaryotic ribonucleases P/MRP: the crystal structure of the P3 domain.,Perederina A, Esakova O, Quan C, Khanova E, Krasilnikov AS EMBO J. 2010 Feb 17;29(4):761-9. Epub 2010 Jan 14. PMID:20075859<ref>PMID:20075859</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3iab" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20075859}}, adds the Publication Abstract to the page
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20075859 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20075859}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3IAB is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAB OCA].
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==Reference==
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<ref group="xtra">PMID:20075859</ref><references group="xtra"/>
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[[Category: Ribonuclease P]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Esakova, O A.]]
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[[Category: Esakova OA]]
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[[Category: Khanova, E.]]
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[[Category: Khanova E]]
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[[Category: Krasilnikov, A S.]]
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[[Category: Krasilnikov AS]]
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[[Category: Perederina, A.]]
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[[Category: Perederina A]]
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[[Category: Quan, C.]]
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[[Category: Quan C]]
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[[Category: Alba]]
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[[Category: Coiled coil]]
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[[Category: Heterodimer]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase/rna complex]]
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[[Category: Nme1]]
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[[Category: Nucleus]]
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[[Category: P3]]
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[[Category: Phosphoprotein]]
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[[Category: Pop6]]
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[[Category: Pop6p]]
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[[Category: Pop7]]
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[[Category: Pop7p]]
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[[Category: Pre-trna]]
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[[Category: Protein-rna complex]]
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[[Category: Ribonuclease mrp]]
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[[Category: Ribonuclease p]]
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[[Category: Ribozyme]]
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[[Category: Rnase mrp]]
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[[Category: Rnase p]]
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[[Category: Rrna]]
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[[Category: Rrna processing]]
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[[Category: Trna]]
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[[Category: Trna processing]]
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[[Category: Yeast]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 19:37:01 2010''
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Current revision

Crystal structure of RNase P /RNase MRP proteins Pop6, Pop7 in a complex with the P3 domain of RNase MRP RNA

PDB ID 3iab

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