3iir

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{{Seed}}
 
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[[Image:3iir.png|left|200px]]
 
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==Crystal Structure of Miraculin like protein from seeds of Murraya koenigii==
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The line below this paragraph, containing "STRUCTURE_3iir", creates the "Structure Box" on the page.
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<StructureSection load='3iir' size='340' side='right'caption='[[3iir]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3iir]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Murraya_koenigii Murraya koenigii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IIR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iir OCA], [https://pdbe.org/3iir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iir RCSB], [https://www.ebi.ac.uk/pdbsum/3iir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iir ProSAT]</span></td></tr>
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{{STRUCTURE_3iir| PDB=3iir | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D2YW43_MURKO D2YW43_MURKO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/3iir_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iir ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Earlier, the purification of a 21.4kDa protein with trypsin inhibitory activity from seeds of Murraya koenigii has been reported. The present study, based on the amino acid sequence deduced from both cDNA and genomic DNA, establishes it to be a miraculin-like protein and provides crystal structure at 2.9A resolution. The mature protein consists of 190 amino acid residues with seven cysteines arranged in three disulfide bridges. The amino acid sequence showed maximum homology and formed a distinct cluster with miraculin-like proteins, a soybean Kunitz super family member, in phylogenetic analyses. The major differences in sequence were observed at primary and secondary specificity sites in the reactive loop when compared to classical Kunitz family members. The crystal structure analysis showed that the protein is made of twelve antiparallel beta-strands, loops connecting beta-strands and two short helices. Despite similar overall fold, it showed significant differences from classical Kunitz trypsin inhibitors.
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===Crystal Structure of Miraculin like protein from seeds of Murraya koenigii===
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Cloning, sequence analysis and crystal structure determination of a miraculin-like protein from Murraya koenigii.,Gahloth D, Selvakumar P, Shee C, Kumar P, Sharma AK Arch Biochem Biophys. 2010 Feb 1;494(1):15-22. Epub 2009 Nov 13. PMID:19914199<ref>PMID:19914199</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3iir" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19914199}}, adds the Publication Abstract to the page
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*[[Miraculin|Miraculin]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19914199 is the PubMed ID number.
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*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
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-->
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== References ==
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{{ABSTRACT_PUBMED_19914199}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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3IIR is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Murraya_koenigii Murraya koenigii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IIR OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:19914199</ref><references group="xtra"/>
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[[Category: Murraya koenigii]]
[[Category: Murraya koenigii]]
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[[Category: Gahloth, D.]]
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[[Category: Gahloth D]]
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[[Category: Kumar, P.]]
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[[Category: Kumar P]]
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[[Category: Selvakumar, P.]]
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[[Category: Selvakumar P]]
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[[Category: Sharma, A K.]]
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[[Category: Sharma AK]]
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[[Category: Shee, C.]]
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[[Category: Shee C]]
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[[Category: Beta-trefoil fold]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Kunitz trypsin inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 20:32:59 2010''
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Current revision

Crystal Structure of Miraculin like protein from seeds of Murraya koenigii

PDB ID 3iir

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