3ju0

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{{Seed}}
 
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[[Image:3ju0.png|left|200px]]
 
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==Structure of the arm-type binding domain of HAI7 integrase==
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The line below this paragraph, containing "STRUCTURE_3ju0", creates the "Structure Box" on the page.
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<StructureSection load='3ju0' size='340' side='right'caption='[[3ju0]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ju0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pectobacterium_atrosepticum Pectobacterium atrosepticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JU0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ju0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ju0 OCA], [https://pdbe.org/3ju0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ju0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ju0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ju0 ProSAT]</span></td></tr>
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{{STRUCTURE_3ju0| PDB=3ju0 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q6D6K1_PECAS Q6D6K1_PECAS]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/3ju0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ju0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structures of the N-terminal domains of two integrases of closely related but not identical asn tDNA-associated genomic islands, Yersinia HPI (high pathogenicity island; encoding siderophore yersiniabactin biosynthesis and transport) and an Erwinia carotovora genomic island with yet unknown function, HAI7, have been resolved. Both integrases utilize a novel four-stranded beta-sheet DNA-binding motif, in contrast to the known proteins that bind their DNA targets by means of three-stranded beta-sheets. Moreover, the beta-sheets in Int(HPI) and Int(HAI7) are longer than those in other integrases, and the structured helical N terminus is positioned perpendicularly to the large C-terminal helix. These differences strongly support the proposal that the integrases of the genomic islands make up a distinct evolutionary branch of the site-specific recombinases that utilize a unique DNA-binding mechanism.
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===Structure of the arm-type binding domain of HAI7 integrase===
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Structures of the arm-type binding domains of HPI and HAI7 integrases.,Szwagierczak A, Antonenka U, Popowicz GM, Sitar T, Holak TA, Rakin A J Biol Chem. 2009 Nov 13;284(46):31664-71. Epub 2009 Sep 8. PMID:19737930<ref>PMID:19737930</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ju0" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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3JU0 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pectobacterium_atrosepticum Pectobacterium atrosepticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JU0 OCA].
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*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pectobacterium atrosepticum]]
[[Category: Pectobacterium atrosepticum]]
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[[Category: Antonenka, U.]]
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[[Category: Antonenka U]]
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[[Category: Holak, T A.]]
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[[Category: Holak TA]]
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[[Category: Popowicz, G M.]]
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[[Category: Popowicz GM]]
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[[Category: Rakin, A.]]
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[[Category: Rakin A]]
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[[Category: Sitar, T.]]
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[[Category: Sitar T]]
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[[Category: Szwagierczak, A.]]
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[[Category: Szwagierczak A]]
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[[Category: Dna binding protein]]
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[[Category: Four stranded beta-sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:27:20 2010''
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Current revision

Structure of the arm-type binding domain of HAI7 integrase

PDB ID 3ju0

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