2wgu

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{{Seed}}
 
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[[Image:2wgu.png|left|200px]]
 
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==Structure of human adenovirus serotype 37 fibre head in complex with a sialic acid derivative, O-Methyl 5-N- methoxycarbonyl -3,5-dideoxy- D-glycero-a-D-galacto-2-nonulopyranosylonic acid==
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The line below this paragraph, containing "STRUCTURE_2wgu", creates the "Structure Box" on the page.
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<StructureSection load='2wgu' size='340' side='right'caption='[[2wgu]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wgu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_D37 Human adenovirus D37]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WGU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=42D:3,5-DIDEOXY-5-[(METHOXYCARBONYL)AMINO]-D-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSONIC+ACID'>42D</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2wgu| PDB=2wgu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wgu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgu OCA], [https://pdbe.org/2wgu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wgu RCSB], [https://www.ebi.ac.uk/pdbsum/2wgu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q64823_9ADEN Q64823_9ADEN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/2wgu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wgu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The adenovirus serotype Ad37 binds to and infects human corneal epithelial (HCE) cells through attachment to cellular glycoproteins carrying terminal sialic acids. By use of the crystallographic structure of the sialic acid-interacting domain of the Ad37 fiber protein in complex with sialyllactose, a set of N-acyl modified sialic acids were designed to improve binding affinity through increased hydrophobic interactions. These N-acyl modified sialic acids and their corresponding multivalent human serum albumin (HSA) conjugates were synthesized and tested in Ad37 cell binding and cell infectivity assays. Compounds bearing small substituents were as effective inhibitors as sialic acid. X-ray crystallography and overlays with the Ad37-sialyllactose complex showed that the N-acyl modified sialic acids were positioned in the same orientation as sialic acid. Their multivalent counterparts achieved a strong multivalency effect and were more effective to prevent infection than the monomers. Unfortunately, they were less active as inhibitors than multivalent sialic acid.
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===STRUCTURE OF HUMAN ADENOVIRUS SEROTYPE 37 FIBRE HEAD IN COMPLEX WITH A SIALIC ACID DERIVATIVE, O-METHYL 5-N-METHOXYCARBONYL -3,5-DIDEOXY-D-GLYCERO-A-D-GALACTO-2-NONULOPYRANOSYLONIC ACID===
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Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis.,Johansson S, Nilsson E, Qian W, Guilligay D, Crepin T, Cusack S, Arnberg N, Elofsson M J Med Chem. 2009 Jun 25;52(12):3666-78. PMID:19456100<ref>PMID:19456100</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19456100}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2wgu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19456100 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19456100}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Human adenovirus D37]]
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2WGU is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Human_adenovirus_37 Human adenovirus 37]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGU OCA].
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[[Category: Large Structures]]
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[[Category: Arnberg N]]
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==Reference==
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[[Category: Crepin T]]
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<ref group="xtra">PMID:19456100</ref><references group="xtra"/>
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[[Category: Cusack S]]
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[[Category: Human adenovirus 37]]
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[[Category: Elofsson M]]
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[[Category: Arnberg, N.]]
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[[Category: Guilligay D]]
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[[Category: Crepin, T.]]
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[[Category: Johansson S]]
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[[Category: Cusack, S.]]
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[[Category: Nilsson E]]
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[[Category: Elofsson, M.]]
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[[Category: Qian W]]
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[[Category: Guilligay, D.]]
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[[Category: Johansson, S.]]
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[[Category: Nilsson, E.]]
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[[Category: Qian, W.]]
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[[Category: Ad37]]
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[[Category: Cd46]]
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[[Category: Conjunctivitis]]
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[[Category: Daf]]
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[[Category: Neuraminic acid]]
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[[Category: Receptor]]
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[[Category: Sialic acid]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:41:01 2010''
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Current revision

Structure of human adenovirus serotype 37 fibre head in complex with a sialic acid derivative, O-Methyl 5-N- methoxycarbonyl -3,5-dideoxy- D-glycero-a-D-galacto-2-nonulopyranosylonic acid

PDB ID 2wgu

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