3ks9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:21, 30 October 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3ks9.png|left|200px]]
 
-
<!--
+
==Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist==
-
The line below this paragraph, containing "STRUCTURE_3ks9", creates the "Structure Box" on the page.
+
<StructureSection load='3ks9' size='340' side='right'caption='[[3ks9]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3ks9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KS9 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr>
-
{{STRUCTURE_3ks9| PDB=3ks9 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ks9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ks9 OCA], [https://pdbe.org/3ks9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ks9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ks9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ks9 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/GRM1_HUMAN GRM1_HUMAN] Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22901947</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GRM1_HUMAN GRM1_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.<ref>PMID:7476890</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ks/3ks9_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ks9 ConSurf].
 +
<div style="clear:both"></div>
-
===Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist===
+
==See Also==
-
 
+
*[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
3KS9 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KS9 OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C.]]
+
[[Category: Bochkarev A]]
-
[[Category: Cossar, D.]]
+
[[Category: Bountra C]]
-
[[Category: Dobrovetsky, E.]]
+
[[Category: Cossar D]]
-
[[Category: Edwards, A M.]]
+
[[Category: Dobrovetsky E]]
-
[[Category: Khutoreskaya, G.]]
+
[[Category: Edwards AM]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Khutoreskaya G]]
-
[[Category: Seitova, A.]]
+
[[Category: Seitova A]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt J]]
-
[[Category: Alternative splicing]]
+
-
[[Category: Cell membrane]]
+
-
[[Category: Dimerization]]
+
-
[[Category: G-protein coupled receptor]]
+
-
[[Category: Glutamate receptor]]
+
-
[[Category: Glutamic acid binding]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Membrane]]
+
-
[[Category: Mglur1]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Receptor]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Transducer]]
+
-
[[Category: Transmembrane]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:46:36 2010''
+

Current revision

Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist

PDB ID 3ks9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ks9"
Personal tools