3kg4

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[[Image:3kg4.png|left|200px]]
 
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==Crystal structure of an uncharacterized protein from Mannheimia succiniciproducens==
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The line below this paragraph, containing "STRUCTURE_3kg4", creates the "Structure Box" on the page.
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<StructureSection load='3kg4' size='340' side='right'caption='[[3kg4]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kg4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mannheimia_succiniciproducens_MBEL55E Mannheimia succiniciproducens MBEL55E]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KG4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kg4 OCA], [https://pdbe.org/3kg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kg4 RCSB], [https://www.ebi.ac.uk/pdbsum/3kg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kg4 ProSAT]</span></td></tr>
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{{STRUCTURE_3kg4| PDB=3kg4 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAS5D_MANSM CAS5D_MANSM] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This protein is a sequence-specific endonuclease that cleaves pre-crRNA at G21 into mature crRNA. Does not cleave pre-crRNA associated with the T.thermophilus strain HB27 Cas5 protein (AC Q746C2) CRISPR locus (PubMed:23006625). The reaction mechanism may proceed by an intramolecular attack of the 2'-hydroxyl group of G21 on the scissile phosphodiester, cutting the precursor 3' to G21 residue yielding 5'-hydroxyl and 2' and/or 3' ends lacking a hydroxyl group (perhaps a 2'/3' cyclic phosphodiester) (Ref.2).<ref>PMID:23006625</ref> <ref>PMID:23006625</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/3kg4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kg4 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of an uncharacterized protein from Mannheimia succiniciproducens===
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==See Also==
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*[[CRISPR subtype I-C|CRISPR subtype I-C]]
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*[[CRISPR-Cas|CRISPR-Cas]]
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==About this Structure==
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== References ==
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3KG4 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mannheimia_succiniciproducens_mbel55e Mannheimia succiniciproducens mbel55e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KG4 OCA].
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<references/>
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[[Category: Mannheimia succiniciproducens mbel55e]]
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__TOC__
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[[Category: Almo, S C.]]
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</StructureSection>
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[[Category: Bain, K T.]]
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[[Category: Large Structures]]
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[[Category: Bonanno, J B.]]
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[[Category: Almo SC]]
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[[Category: Burley, S K.]]
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[[Category: Bain KT]]
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[[Category: Dickey, M.]]
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[[Category: Bonanno JB]]
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[[Category: Lau, C.]]
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[[Category: Burley SK]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
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[[Category: Dickey M]]
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[[Category: Romero, R.]]
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[[Category: Lau C]]
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[[Category: Sauder, J M.]]
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[[Category: Romero R]]
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[[Category: Wasserman, S.]]
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[[Category: Sauder JM]]
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[[Category: New york sgx research center for structural genomic]]
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[[Category: Wasserman S]]
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[[Category: Nysgxrc]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:53:32 2010''
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Current revision

Crystal structure of an uncharacterized protein from Mannheimia succiniciproducens

PDB ID 3kg4

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