3gny

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:08, 6 September 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3gny.png|left|200px]]
 
-
<!--
+
==Crystal structure of human alpha-defensin 1 (HNP1)==
-
The line below this paragraph, containing "STRUCTURE_3gny", creates the "Structure Box" on the page.
+
<StructureSection load='3gny' size='340' side='right'caption='[[3gny]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3gny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GNY FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
{{STRUCTURE_3gny| PDB=3gny | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gny OCA], [https://pdbe.org/3gny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gny RCSB], [https://www.ebi.ac.uk/pdbsum/3gny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gny ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DEF1_HUMAN DEF1_HUMAN]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Despite the small size and conserved tertiary structure of defensins, little is known at a molecular level about the basis of their functional versatility. For insight into the mechanism(s) of defensin function, we prepared enantiomeric pairs of four human defensins, HNP1, HNP4, HD5, and HBD2, and studied their killing of bacteria, inhibition of anthrax lethal factor, and binding to HIV-1 gp120. Unstructured HNP1, HD5, and HBD3 and several other human alpha- and beta-defensins were also examined. Crystallographic analysis showed a plane of symmetry that related (L)HNP1 and (D)HNP1 to each other. Either d-enantiomerization or linearization significantly impaired the ability of HNP1 and HD5 to kill Staphylococcus aureus but not Escherichia coli. In contrast, (L)HNP4 and (D)HNP4 were equally bactericidal against both bacteria. d-Enantiomers were generally weaker inhibitors or binders of lethal factor and gp120 than their respective native, all-l forms, although activity differences were modest, particularly for HNP4. A strong correlation existed among these different functions. Our data indicate: (a) that HNP1 and HD5 kill E. coli by a process that is mechanistically distinct from their actions that kill S. aureus and (b) that chiral molecular recognition is not a stringent prerequisite for other functions of these defensins, including their ability to inhibit lethal factor and bind gp120 of HIV-1.
-
===Crystal structure of human alpha-defensin 1 (HNP1)===
+
Through the looking glass, mechanistic insights from enantiomeric human defensins.,Wei G, de Leeuw E, Pazgier M, Yuan W, Zou G, Wang J, Ericksen B, Lu WY, Lehrer RI, Lu W J Biol Chem. 2009 Oct 16;284(42):29180-92. Epub 2009 Jul 29. PMID:19640840<ref>PMID:19640840</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3gny" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_19640840}}, adds the Publication Abstract to the page
+
*[[Defensin 3D structures|Defensin 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 19640840 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_19640840}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Homo sapiens]]
-
3GNY is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GNY OCA].
+
[[Category: Large Structures]]
-
 
+
[[Category: Lu W-Y]]
-
==Reference==
+
[[Category: Pazgier M]]
-
<ref group="xtra">PMID:19640840</ref><references group="xtra"/>
+
-
[[Category: Lu, W-Y.]]
+
-
[[Category: Pazgier, M.]]
+
-
[[Category: Antibiotic]]
+
-
[[Category: Antimicrobial]]
+
-
[[Category: Antimicrobial peptide]]
+
-
[[Category: Antimicrobial protein]]
+
-
[[Category: Antiviral defense]]
+
-
[[Category: Defensin]]
+
-
[[Category: Disulfide bond]]
+
-
[[Category: Fungicide]]
+
-
[[Category: Hnp1]]
+
-
[[Category: Human alpha defensin 1]]
+
-
[[Category: Human neutrophil peptide 1]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Secreted]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 09:09:43 2010''
+

Current revision

Crystal structure of human alpha-defensin 1 (HNP1)

PDB ID 3gny

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools