3kbt

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{{Seed}}
 
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[[Image:3kbt.jpg|left|200px]]
 
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==Crystal structure of the ankyrin binding domain of human erythroid beta spectrin (repeats 13-15) in complex with the spectrin binding domain of human erythroid ankyrin (ZU5-ANK)==
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The line below this paragraph, containing "STRUCTURE_3kbt", creates the "Structure Box" on the page.
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<StructureSection load='3kbt' size='340' side='right'caption='[[3kbt]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kbt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KBT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kbt OCA], [https://pdbe.org/3kbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kbt RCSB], [https://www.ebi.ac.uk/pdbsum/3kbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kbt ProSAT]</span></td></tr>
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{{STRUCTURE_3kbt| PDB=3kbt | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SPTB1_HUMAN SPTB1_HUMAN] Defects in SPTB are the cause of elliptocytosis type 3 (EL3) [MIM:[https://omim.org/entry/182870 182870]. EL3 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.<ref>PMID:8226774</ref> <ref>PMID:7883966</ref> <ref>PMID:8018926</ref> <ref>PMID:1975598</ref> Defects in SPTB are the cause of spherocytosis type 2 (SPH2) [MIM:[https://omim.org/entry/182870 182870]; also known as hereditary spherocytosis type 2 (HS2). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH2 is characterized by severe hemolytic anemia. Inheritance is autosomal dominant.
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== Function ==
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[https://www.uniprot.org/uniprot/SPTB1_HUMAN SPTB1_HUMAN] Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/3kbt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kbt ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the ankyrin binding domain of human erythroid beta spectrin (repeats 13-15) in complex with the spectrin binding domain of human erythroid ankyrin (ZU5-ANK)===
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==See Also==
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*[[Ankyrin 3D structures|Ankyrin 3D structures]]
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*[[Spectrin 3D structures|Spectrin 3D structures]]
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== References ==
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 19141864 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_19141864}}
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==About this Structure==
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3KBT is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KBT OCA].
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==Reference==
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<ref group="xtra">PMID:19141864</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ipsaro, J J.]]
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[[Category: Large Structures]]
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[[Category: Mondragon, A.]]
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[[Category: Ipsaro JJ]]
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[[Category: Actin capping]]
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[[Category: Mondragon A]]
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[[Category: Actin-binding]]
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[[Category: Alternative promoter usage]]
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[[Category: Alternative splicing]]
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[[Category: Ank repeat]]
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[[Category: Ankyrin]]
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[[Category: Ankyrin binding]]
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[[Category: Beta sandwich]]
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[[Category: Complex]]
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[[Category: Cytoplasm]]
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[[Category: Cytoskeleton]]
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[[Category: Disease mutation]]
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[[Category: Elliptocytosis]]
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[[Category: Hereditary hemolytic anemia]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Membrane skeleton]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Sarcoplasmic reticulum]]
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[[Category: Spectrin]]
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[[Category: Spectrin binding]]
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[[Category: Spectrin repeat]]
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[[Category: Structural protein]]
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[[Category: Three helix bundle]]
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[[Category: Zu5]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 09:34:42 2010''
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Current revision

Crystal structure of the ankyrin binding domain of human erythroid beta spectrin (repeats 13-15) in complex with the spectrin binding domain of human erythroid ankyrin (ZU5-ANK)

PDB ID 3kbt

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OCA

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