3jt1

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[[Image:3jt1.jpg|left|200px]]
 
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==Legionella pneumophila glucosyltransferase Lgt1, UDP-bound form==
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The line below this paragraph, containing "STRUCTURE_3jt1", creates the "Structure Box" on the page.
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<StructureSection load='3jt1' size='340' side='right'caption='[[3jt1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3jt1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_str._Lens Legionella pneumophila str. Lens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JT1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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{{STRUCTURE_3jt1| PDB=3jt1 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jt1 OCA], [https://pdbe.org/3jt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jt1 RCSB], [https://www.ebi.ac.uk/pdbsum/3jt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jt1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5WWY0_LEGPL Q5WWY0_LEGPL]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The glucosyltransferase Lgt1 is one of three glucosylating toxins of Legionella pneumophila, the causative agent of Legionnaires disease. It acts through specific glucosylation of a serine residue (S53) in the eukaryotic elongation factor 1A and belongs to type A glycosyltransferases. High-resolution crystal structures of Lgt1 show an elongated shape of the protein, with the binding site for uridine disphosphate glucose at the bottom of a deep cleft. Lgt1 shows only a low sequence identity with other type A glycosyltransferases, and structural conservation is limited to a central folding core that is usually observed within this family of proteins. Domains and protrusions added to the core motif represent determinants for the specific recognition and binding of the target. Manual docking experiments based on the crystal structures of toxin and target protein suggest an obvious mode of binding to the target that allows for efficient transfer of a glucose moiety.
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===Legionella pneumophila glucosyltransferase Lgt1, UDP-bound form===
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Structural basis of the action of glucosyltransferase Lgt1 from Legionella pneumophila.,Lu W, Du J, Stahl M, Tzivelekidis T, Belyi Y, Gerhardt S, Aktories K, Einsle O J Mol Biol. 2010 Feb 19;396(2):321-31. Epub 2009 Nov 23. PMID:19941871<ref>PMID:19941871</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19941871}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3jt1" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19941871 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19941871}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3JT1 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JT1 OCA].
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[[Category: Legionella pneumophila str. Lens]]
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[[Category: Aktories K]]
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==Reference==
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[[Category: Belyi Y]]
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<ref group="xtra">PMID:19941871</ref><references group="xtra"/>
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[[Category: Du J]]
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[[Category: Legionella pneumophila]]
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[[Category: Einsle O]]
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[[Category: Aktories, K.]]
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[[Category: Gerhardt S]]
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[[Category: Belyi, Y.]]
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[[Category: Lu W]]
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[[Category: Du, J.]]
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[[Category: Stahl M]]
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[[Category: Einsle, O.]]
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[[Category: Zivilikidis T]]
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[[Category: Gerhardt, S.]]
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[[Category: Lu, W.]]
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[[Category: Stahl, M.]]
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[[Category: Zivilikidis, T.]]
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[[Category: Glucosyltransferase]]
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[[Category: Legionella pneumophila]]
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[[Category: Legionnaire's disease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 09:36:00 2010''
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Current revision

Legionella pneumophila glucosyltransferase Lgt1, UDP-bound form

PDB ID 3jt1

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