2x35

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{{Seed}}
 
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[[Image:2x35.jpg|left|200px]]
 
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==Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.==
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The line below this paragraph, containing "STRUCTURE_2x35", creates the "Structure Box" on the page.
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<StructureSection load='2x35' size='340' side='right'caption='[[2x35]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2x35]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X35 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x35 OCA], [https://pdbe.org/2x35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x35 RCSB], [https://www.ebi.ac.uk/pdbsum/2x35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x35 ProSAT]</span></td></tr>
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{{STRUCTURE_2x35| PDB=2x35 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x3/2x35_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x35 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Trimethylation of Lys36 in histone H3 (H3K36me3) coordinates events associated with the elongation phase of transcription and is also emerging as an important epigenetic regulator of cell growth and differentiation. We have identified the PWWP domain of bromo and plant homeodomain (PHD) finger-containing protein 1 (BRPF1) as a H3K36me3 binding module and have determined the structure of this domain in complex with an H3K36me3-derived peptide.
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===MOLECULAR BASIS OF HISTONE H3K36ME3 RECOGNITION BY THE PWWP DOMAIN OF BRPF1.===
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Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1.,Vezzoli A, Bonadies N, Allen MD, Freund SM, Santiveri CM, Kvinlaug BT, Huntly BJ, Gottgens B, Bycroft M Nat Struct Mol Biol. 2010 May;17(5):617-9. Epub 2010 Apr 18. PMID:20400950<ref>PMID:20400950</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2x35" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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2X35 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X35 OCA].
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*[[Peregrin|Peregrin]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Allen, M D.]]
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[[Category: Large Structures]]
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[[Category: Bonadies, N.]]
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[[Category: Allen MD]]
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[[Category: Bycroft, M.]]
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[[Category: Bonadies N]]
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[[Category: Freund, S M.V.]]
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[[Category: Bycroft M]]
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[[Category: Gottgens, B.]]
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[[Category: Freund SMV]]
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[[Category: Huntly, B J.P.]]
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[[Category: Gottgens B]]
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[[Category: Kvinlaug, B.]]
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[[Category: Huntly BJP]]
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[[Category: Santiveri, C M.]]
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[[Category: Kvinlaug B]]
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[[Category: Vezzoli, A.]]
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[[Category: Santiveri CM]]
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[[Category: Chromatin regulator]]
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[[Category: Vezzoli A]]
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[[Category: Dna-binding]]
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[[Category: Metal-binding]]
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[[Category: Nucleosome]]
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[[Category: Phosphoprotein]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Trimethylated lysine]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 09:50:53 2010''
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Current revision

Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1.

PDB ID 2x35

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