3hsk

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{{Seed}}
 
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[[Image:3hsk.jpg|left|200px]]
 
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==Crystal Structure of Aspartate Semialdehyde Dehydrogenase with NADP from Candida albicans==
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The line below this paragraph, containing "STRUCTURE_3hsk", creates the "Structure Box" on the page.
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<StructureSection load='3hsk' size='340' side='right'caption='[[3hsk]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3hsk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HSK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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{{STRUCTURE_3hsk| PDB=3hsk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsk OCA], [https://pdbe.org/3hsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hsk RCSB], [https://www.ebi.ac.uk/pdbsum/3hsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5ALM0_CANAL Q5ALM0_CANAL]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/3hsk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hsk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The enzyme aspartate semialdehyde dehydrogenase (ASADH) catalyzes a critical transformation that produces the first branch-point intermediate in an essential microbial amino-acid biosynthetic pathway. The first structure of an ASADH isolated from a fungal species (Candida albicans) has been determined as a complex with its pyridine nucleotide cofactor. This enzyme is a functional dimer, with a similar overall fold and domain organization to the structurally characterized bacterial ASADHs. However, there are differences in the secondary-structural elements and in cofactor binding that are likely to cause the lower catalytic efficiency of this fungal enzyme. Alterations in the dimer interface, through deletion of a helical subdomain and replacement of amino acids that participate in a hydrogen-bonding network, interrupt the intersubunit-communication channels required to support an alternating-site catalytic mechanism. The detailed functional information derived from this new structure will allow an assessment of ASADH as a possible target for antifungal drug development.
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===Crystal Structure of Aspartate Semialdehyde Dehydrogenase with NADP from Candida albicans===
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Expansion of the aspartate beta-semialdehyde dehydrogenase family: the first structure of a fungal ortholog.,Arachea BT, Liu X, Pavlovsky AG, Viola RE Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):205-12. Epub 2010, Jan 22. PMID:20124701<ref>PMID:20124701</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3hsk" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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3HSK is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSK OCA].
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*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
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[[Category: Aspartate-semialdehyde dehydrogenase]]
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*[[Aspartate-semialdehyde dehydrogenase 3D structures|Aspartate-semialdehyde dehydrogenase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Candida albicans]]
[[Category: Candida albicans]]
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[[Category: Arachea, B T.]]
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[[Category: Large Structures]]
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[[Category: Liu, X.]]
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[[Category: Arachea BT]]
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[[Category: Pavlovsky, A.]]
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[[Category: Liu X]]
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[[Category: Viola, R E.]]
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[[Category: Pavlovsky A]]
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[[Category: Amino-acid biosynthesis]]
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[[Category: Viola RE]]
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[[Category: Aspartate semialdehyde dehydrogenase]]
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[[Category: Candida albicans nadp complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 09:54:14 2010''
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Current revision

Crystal Structure of Aspartate Semialdehyde Dehydrogenase with NADP from Candida albicans

PDB ID 3hsk

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