3ik5

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{{Seed}}
 
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[[Image:3ik5.jpg|left|200px]]
 
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==SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)==
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The line below this paragraph, containing "STRUCTURE_3ik5", creates the "Structure Box" on the page.
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<StructureSection load='3ik5' size='340' side='right'caption='[[3ik5]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ik5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus_-_cpz Simian immunodeficiency virus - cpz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IK5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ik5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik5 OCA], [https://pdbe.org/3ik5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ik5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ik5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik5 ProSAT]</span></td></tr>
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{{STRUCTURE_3ik5| PDB=3ik5 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEF_SIVMA NEF_SIVMA] Seems to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Enhances virus infectivity and pathogenicity. Probably involved in viral immune evasion mechanisms (By similarity). In infected CD4(+) T-lymphocytes, down-regulates cell surface expression of CD4, CD28, CD3, and MHC-I or MHC-II molecules. Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/3ik5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ik5 ConSurf].
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<div style="clear:both"></div>
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===SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)===
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==See Also==
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*[[CD3 3D structures|CD3 3D structures]]
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*[[Protein Nef 3D structures|Protein Nef 3D structures]]
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==About this Structure==
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__TOC__
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3IK5 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK5 OCA].
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</StructureSection>
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[[Category: Simian immunodeficiency virus]]
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[[Category: Homo sapiens]]
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[[Category: Kim, W M.]]
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[[Category: Large Structures]]
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[[Category: Sigalov, A B.]]
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[[Category: Simian immunodeficiency virus - cpz]]
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[[Category: Stern, L J.]]
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[[Category: Kim WM]]
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[[Category: Alternative splicing]]
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[[Category: Sigalov AB]]
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[[Category: Cell membrane]]
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[[Category: Stern LJ]]
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[[Category: Disulfide bond]]
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[[Category: Host-virus interaction]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Myristate]]
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[[Category: Phosphoprotein]]
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[[Category: Protein-protein complex]]
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[[Category: Receptor]]
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[[Category: Transmembrane]]
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[[Category: Viral immunoevasion]]
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[[Category: Viral protein/antiviral protein complex]]
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[[Category: Viral protein/signaling protein complex]]
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[[Category: Virulence]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 09:55:04 2010''
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Current revision

SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)

PDB ID 3ik5

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