3jxi

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{{Seed}}
 
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[[Image:3jxi.png|left|200px]]
 
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==Crystal structure of the chicken TRPV4 ankyrin repeat domain==
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The line below this paragraph, containing "STRUCTURE_3jxi", creates the "Structure Box" on the page.
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<StructureSection load='3jxi' size='340' side='right'caption='[[3jxi]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3jxi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JXI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jxi OCA], [https://pdbe.org/3jxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jxi RCSB], [https://www.ebi.ac.uk/pdbsum/3jxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jxi ProSAT]</span></td></tr>
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{{STRUCTURE_3jxi| PDB=3jxi | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRPV4_CHICK TRPV4_CHICK] Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11081638). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:11081638). Also activated by phorbol esters (PubMed:19864432). Channel activity seems to be regulated by a calmodulin-dependent mechanism (By similarity).[UniProtKB:Q9HBA0]<ref>PMID:11081638</ref> <ref>PMID:19864432</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/3jxi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jxi ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Charcot-Marie-Tooth disease type 2C (CMT2C) is an autosomal dominant neuropathy characterized by limb, diaphragm and laryngeal muscle weakness. Two unrelated families with CMT2C showed significant linkage to chromosome 12q24.11. We sequenced all genes in this region and identified two heterozygous missense mutations in the TRPV4 gene, C805T and G806A, resulting in the amino acid substitutions R269C and R269H. TRPV4 is a well-known member of the TRP superfamily of cation channels. In TRPV4-transfected cells, the CMT2C mutations caused marked cellular toxicity and increased constitutive and activated channel currents. Mutations in TRPV4 were previously associated with skeletal dysplasias. Our findings indicate that TRPV4 mutations can also cause a degenerative disorder of the peripheral nerves. The CMT2C-associated mutations lie in a distinct region of the TRPV4 ankyrin repeats, suggesting that this phenotypic variability may be due to differential effects on regulatory protein-protein interactions.
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===Crystal structure of the chicken TRPV4 ankyrin repeat domain===
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Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C.,Landoure G, Zdebik AA, Martinez TL, Burnett BG, Stanescu HC, Inada H, Shi Y, Taye AA, Kong L, Munns CH, Choo SS, Phelps CB, Paudel R, Houlden H, Ludlow CL, Caterina MJ, Gaudet R, Kleta R, Fischbeck KH, Sumner CJ Nat Genet. 2010 Feb;42(2):170-4. Epub 2009 Dec 27. PMID:20037586<ref>PMID:20037586</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3jxi" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20037586}}, adds the Publication Abstract to the page
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20037586 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20037586}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3JXI is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXI OCA].
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==Reference==
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<ref group="xtra">PMID:20037586</ref><references group="xtra"/>
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Gaudet, R.]]
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[[Category: Large Structures]]
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[[Category: Phelps, C B.]]
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[[Category: Gaudet R]]
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[[Category: Wang, R R.]]
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[[Category: Phelps CB]]
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[[Category: Ank repeat]]
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[[Category: Wang RR]]
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[[Category: Ankyrin repeat]]
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[[Category: Ion transport]]
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[[Category: Ionic channel]]
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[[Category: Membrane protein]]
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[[Category: Receptor]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 15:59:07 2010''
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Current revision

Crystal structure of the chicken TRPV4 ankyrin repeat domain

PDB ID 3jxi

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