3a7b

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{{Seed}}
 
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[[Image:3a7b.png|left|200px]]
 
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==Crystal structure of TLR2-Streptococcus Pneumoniae lipoteichoic acid complex==
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The line below this paragraph, containing "STRUCTURE_3a7b", creates the "Structure Box" on the page.
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<StructureSection load='3a7b' size='340' side='right'caption='[[3a7b]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3a7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A7B FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LTC:(2S)-1-({3-O-[2-(ACETYLAMINO)-4-AMINO-2,4,6-TRIDEOXY-BETA-D-GALACTOPYRANOSYL]-ALPHA-D-GLUCOPYRANOSYL}OXY)-3-(HEPTANOYLOXY)PROPAN-2-YL+(7Z)-PENTADEC-7-ENOATE'>LTC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_3a7b| PDB=3a7b | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a7b OCA], [https://pdbe.org/3a7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a7b RCSB], [https://www.ebi.ac.uk/pdbsum/3a7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a7b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TLR2_MOUSE TLR2_MOUSE] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (By similarity).<ref>PMID:19931471</ref> [https://www.uniprot.org/uniprot/Q4G1L2_EPTBU Q4G1L2_EPTBU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a7/3a7b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a7b ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA complexes. PE-DTPA, 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepenta acetic acid, is a synthetic phospholipid derivative. Two major factors contribute to the ligand specificity of TLR2-TLR1 or TLR2-TLR6 heterodimers. First, the lipid channel of TLR6 is blocked by two phenylalanines. Simultaneous mutation of these phenylalanines made TLR2-TLR6 fully responsive not only to diacylated but also to triacylated lipopeptides. Second, the hydrophobic dimerization interface of TLR2-TLR6 is increased by 80%, which compensates for the lack of amide lipid interaction between the lipopeptide and TLR2-TLR6. The structures of the TLR2-lipoteichoic acid and the TLR2-PE-DTPA complexes demonstrate that a precise interaction pattern of the head group is essential for a robust immune response by TLR2 heterodimers.
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===Crystal structure of TLR2-Streptococcus Pneumoniae lipoteichoic acid complex===
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Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.,Kang JY, Nan X, Jin MS, Youn SJ, Ryu YH, Mah S, Han SH, Lee H, Paik SG, Lee JO Immunity. 2009 Dec 18;31(6):873-84. PMID:19931471<ref>PMID:19931471</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3a7b" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19931471}}, adds the Publication Abstract to the page
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19931471 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19931471}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Eptatretus burgeri]]
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3A7B is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus,_eptatretus_burgeri Mus musculus, eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A7B OCA].
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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==Reference==
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[[Category: Jin MS]]
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<ref group="xtra">PMID:19931471</ref><references group="xtra"/>
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[[Category: Kang JY]]
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[[Category: Mus musculus, eptatretus burgeri]]
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[[Category: Lee J-O]]
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[[Category: Jin, M S.]]
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[[Category: Kang, J Y.]]
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[[Category: Lee, J O.]]
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[[Category: Cell membrane]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Immune response]]
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[[Category: Immune system]]
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[[Category: Inflammatory response]]
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[[Category: Leucine rich repeat]]
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[[Category: Lipoteichoic acid]]
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[[Category: Membrane]]
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[[Category: Phosphoprotein]]
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[[Category: Receptor]]
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[[Category: Toll-like receptor]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 16:00:53 2010''
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Current revision

Crystal structure of TLR2-Streptococcus Pneumoniae lipoteichoic acid complex

PDB ID 3a7b

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