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2rqp

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{{Seed}}
 
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[[Image:2rqp.png|left|200px]]
 
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==The Solution Structure of Heterochromatin Protein 1-Binding Protein 74 Histone H1 like domain==
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The line below this paragraph, containing "STRUCTURE_2rqp", creates the "Structure Box" on the page.
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<StructureSection load='2rqp' size='340' side='right'caption='[[2rqp]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rqp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqp OCA], [https://pdbe.org/2rqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rqp RCSB], [https://www.ebi.ac.uk/pdbsum/2rqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqp ProSAT]</span></td></tr>
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{{STRUCTURE_2rqp| PDB=2rqp | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HP1B3_HUMAN HP1B3_HUMAN] Component of heterochromatin, may be involved in chromatin structure and function (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rqp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rqp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In higher eukaryotic cells, DNA molecules are present as chromatin fibers, complexes of DNA with various types of proteins; chromatin fibers are highly condensed in metaphase chromosomes during mitosis. Although the formation of the metaphase chromosome structure is essential for the equal segregation of replicated chromosomal DNA into the daughter cells, the mechanism involved in the organization of metaphase chromosomes is poorly understood. To identify proteins involved in the formation and/or maintenance of metaphase chromosomes, we examined proteins that dissociated from isolated human metaphase chromosomes by 0.4 m NaCl treatment; this treatment led to significant chromosome decondensation, but the structure retained the core histones. One of the proteins identified, HP1-BP74 (heterochromatin protein 1-binding protein 74), composed of 553 amino acid residues, was further characterized. HP1-BP74 middle region (BP74Md), composed of 178 amino acid residues (Lys(97)-Lys(274)), formed a chromatosome-like structure with reconstituted mononucleosomes and protected the linker DNA from micrococcal nuclease digestion by approximately 25 bp. The solution structure determined by NMR revealed that the globular domain (Met(153)-Thr(237)) located within BP74Md possesses a structure similar to that of the globular domain of linker histones, which underlies its nucleosome binding properties. Moreover, we confirmed that BP74Md and full-length HP1-BP74 directly binds to HP1 (heterochromatin protein 1) and identified the exact sites responsible for this interaction. Thus, we discovered that HP1-BP74 directly binds to HP1, and its middle region associates with linker DNA at the entry/exit site of nucleosomal DNA in vitro.
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===The Solution Structure of Heterochromatin Protein 1-Binding Protein 74 Histone H1 like domain===
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The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA.,Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K J Biol Chem. 2010 Feb 26;285(9):6498-507. Epub 2009 Dec 30. PMID:20042602<ref>PMID:20042602</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20042602}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2rqp" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20042602 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20042602}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2RQP is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQP OCA].
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==Reference==
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<ref group="xtra">PMID:20042602</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ohkubo, T.]]
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[[Category: Large Structures]]
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[[Category: Shimamoto, S.]]
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[[Category: Ohkubo T]]
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[[Category: Sugahara, H.]]
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[[Category: Shimamoto S]]
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[[Category: Alternative splicing]]
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[[Category: Sugahara H]]
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[[Category: Chromosomal protein]]
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[[Category: Dna-binding]]
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[[Category: Gene regulation]]
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[[Category: Heterochromatin protein 1]]
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[[Category: Heterochromatin protein 1 binding protein]]
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[[Category: Histone h1]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 16:02:08 2010''
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Current revision

The Solution Structure of Heterochromatin Protein 1-Binding Protein 74 Histone H1 like domain

PDB ID 2rqp

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