2ksn

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'''Unreleased structure'''
 
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The entry 2ksn is ON HOLD until Paper Publication
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==Solution Structure of the N-terminal Domain of DC-UbP/UBTD2==
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<StructureSection load='2ksn' size='340' side='right'caption='[[2ksn]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ksn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KSN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ksn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ksn OCA], [https://pdbe.org/2ksn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ksn RCSB], [https://www.ebi.ac.uk/pdbsum/2ksn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ksn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UBTD2_HUMAN UBTD2_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ks/2ksn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ksn ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DC-UbP/UBTD2 is a ubiquitin (Ub) domain-containing protein first identified from dendritic cells, and is implicated in ubiquitination pathway. The solution structure and backbone dynamics of the C-terminal Ub-like (UbL) domain were elucidated in our previous work. To further understand the biological function of DC-UbP, we then solved the solution structure of the N-terminal domain of DC-UbP (DC-UbP_N) and studied its Ub binding properties by NMR techniques. The results show that DC-UbP_N holds a novel structural fold and acts as a Ub-binding domain (UBD) but with low affinity. This implies that the DC-UbP protein, composing of a combination of both UbL and UBD domains, might play an important role in regulating protein ubiquitination and delivery of ubiquitinated substrates in eukaryotic cells.
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Authors: Song, A., Zhou, C., Guan, X., Sze, K., Hu, H.
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Solution structure of the N-terminal domain of DC-UbP/UBTD2 and its interaction with ubiquitin.,Song AX, Zhou CJ, Guan X, Sze KH, Hu HY Protein Sci. 2010 May;19(5):1104-9. PMID:20440844<ref>PMID:20440844</ref>
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Description: Solution Structure of the N-terminal Domain of DC-UbP/UBTD2
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 16:51:43 2010''
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<div class="pdbe-citations 2ksn" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Guan X]]
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[[Category: Hu H]]
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[[Category: Song A]]
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[[Category: Sze K]]
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[[Category: Zhou C]]

Current revision

Solution Structure of the N-terminal Domain of DC-UbP/UBTD2

PDB ID 2ksn

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