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3e50

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{{Seed}}
 
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[[Image:3e50.png|left|200px]]
 
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<!--
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==Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha==
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The line below this paragraph, containing "STRUCTURE_3e50", creates the "Structure Box" on the page.
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<StructureSection load='3e50' size='340' side='right'caption='[[3e50]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3e50]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E50 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3e50| PDB=3e50 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e50 OCA], [https://pdbe.org/3e50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e50 RCSB], [https://www.ebi.ac.uk/pdbsum/3e50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e50 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/3e50_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e50 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha===
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==See Also==
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*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19896952}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19896952 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19896952}}
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==About this Structure==
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3E50 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E50 OCA].
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==Reference==
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<ref group="xtra">PMID:19896952</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Insulysin]]
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[[Category: Large Structures]]
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[[Category: Guo, Q.]]
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[[Category: Guo Q]]
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[[Category: Manolopoulou,M.]]
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[[Category: Manolopoulou M]]
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[[Category: Tang, W J.]]
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[[Category: Tang W-J]]
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[[Category: Cell membrane]]
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[[Category: Cytoplasm]]
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[[Category: Egf-like domain]]
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[[Category: Glycoprotein]]
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[[Category: Growth factor]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase/hormone complex]]
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[[Category: Ide]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Metalloprotease]]
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[[Category: Mitogen]]
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[[Category: Palmitate]]
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[[Category: Polymorphism]]
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[[Category: Protease]]
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[[Category: Secreted]]
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[[Category: Tgf-alpha]]
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[[Category: Transmembrane]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 18:11:27 2010''
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Current revision

Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha

PDB ID 3e50

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